不同严重程度急性颅脑损伤患者血糖及TNF-α、CRP、PCT水平的变化

doi:10.3969/j.issn.1671-7171.2025.04.033

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Abstract 【Objective】To investigate the levels of fasting blood glucose (FPG), glycosylated hemoglobin a1c (HbA1c), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) and procalcitonin (PCT) in patients with acute craniocerebral injury (ABI) of different severity. 【Methods】A total of 139 ABI patients admitted to our hospital from January 2020 to June 2022 were selected. According to the Glasgow coma score (GCS) within 24 hours of admission, patients were divided into the mild group (GCS of 13-15,n=43), the moderate group (GCS of 9-12, n=9) and the severe group (GCS of 3-8,n=50). At the same time period, 40 healthy volunteers were selected as the control group. The differences of FPG, HbA1c, TNF-α, CRP, PCT among the four groups were compared. Spearman rank correlation analysis was used to explore the relationship of the severity of the disease with levels of FPG, HbA1c, TNF-α, CRP, and PCT in ABI patients. 【Results】The levels of FPG and HbA1c in the control group were lower than those in the mild, moderate and severe groups (P<0.05); FPG and HbA1c levels in the mild group were lower than those in the moderate and severe groups (P<0.05); And FPG and HbA1c levels in the moderate group were lower than those in the severe group (P<0.05). TNF-α, CRP and PCT levels in the control group were lower than those in mild, moderate and severe groups (P<0.05); The levels of TNF-α, CRP and PCT in the mild group were lower than those in the moderate and severe group (P<0.05); And TNF-α, CRP and PCT levels in the moderate group were lower than those in the severe group (P<0.05). Spearman correlation showed that FPG, HbA1c, TNF-α, CRP, and PCT were positively correlated with the severity of ABI (P<0.05). 【Conclusion】Compared to healthy people, the levels of FPG, HbA1c, TNF-α, CRP and PCT in ABI patients are elevated. And FPG, HbA1c, TNF-α, CRP and PCT levels are positively correlated with the severity of the disease, which is worthy of clinical attention.

Key words： Craniocerebral Trauma Acute Disease Blood Glucose Tumor Necrosis Factor-alpha C-Reactive Protein Procalcitonin

Received: 25 June 2024

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R651.15

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WANG Xiaowei. Observation of Blood Glucose, TNF-α, CRP and PCT Levels in Patients with Acute Craniocerebral Injury of Different Severity[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(4): 676-679.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.04.033 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I4/676

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