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| Clinical Effects of High-Flow Nasal Cannula Oxygen Therapy and Non-Invasive Positive Pressure Ventilation in Patients with Pulmonary Edema |
| WANG Jing, WU Chao, LIU Dong |
| Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Shihezi University, Shihezi Xinjiang 832000 |
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Abstract 【Objective】Objective To investigate the clinical effects of high-flow nasal cannula oxygen therapy(HFNC)and non-invasive positive pressure ventilation(NIPPV)in patients with pulmonary edema.【Methods】The clinical data of 166 patients with pulmonary edema treated in our hospital from September 2021 to September 2024 were retrospectively analyzed. Among them,86 patients received NIPPV(the control group)and 80 patients received HFNC(the observation group).Further,65 cases were selected from each group using propensity score matching as the study subjects. The improvement of symptoms and arterial oxygen partial pressure(PaO2),arterial carbon dioxide partial pressure(PaCO2),oxygen saturation(SpO2),mean arterial pressure(MAP),heart rate(HR),respiratory rate(RR),peak expiratory flow(PEF),forced expiratory volume in the first second(FEV1),and the ratio of FEV1 to forced vital capacity(FEV1/FVC)before and 2 days after treatment were compared between the two groups. The incidence of complications during treatment and 28-day mortality were also statistically analyzed. 【Results】The tracheal intubation rate within 7 days in the observation group was lower than that in the control group. The duration of non-invasive ventilation, the time for disappearance of bilateral lung rales, the time for complete disappearance of pulmonary edema, and the hospital stay were all significantly shorter in the observation group than in the control group(P<0.05).After treatment,PaO2,SpO2,MAP,PEF,FEV1,and FEV1/FVC in the observation group were significantly higher than those in the control group(P<0.05),while PaCO2, HR, and RR were significantly lower(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05);however,the 28-day mortality in the observation group was significantly lower than that in the control group(P<0.05). 【Conclusion】 HFNC can significantly improve clinical symptoms in patients with pulmonary edema, reduce the tracheal intubation rate and 28-day mortality, and has high safety.
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Received: 06 March 2025
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2025, Vol. 42 
