泼尼松、环孢素A治疗反复自然流产患者的疗效及对患者妊娠结局、血清性激素水平和免疫功能的影响

doi:10.3969/j.issn.1671-7171.2025.03.025

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Abstract 【Objective】To investigate the efficacy of prednisone and cyclosporine A in the treatment of recurrent spontaneous abortion (RSA) and the effects on pregnancy outcomes, serum sex hormones and immune function. 【Methods】A total of 102 RSA patients diagnosed and treated in two hospitals from January 2021 to January 2023 were randomly divided into the observation group [treated with prednisone + cyclosporin A+ progesterone + human chorionic gonadotropin (HCG) + Philovidian] and the control group (progesterone +HCG+ philovidian), with 51 cases in each group. Serum levels of estradiol (E₂), progesterone (P), luteinizing hormone (LH), CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺ were detected before and after treatment in both groups. The rate of re-abortion, full-term pregnancy, successful preterm delivery, successful delivery and complications were compared between the two groups.【Results】After treatment, E₂, P and LH levels in both control and observation groups were higher than those before treatment, and levels of E₂, P and LH in the observation group was higher than those in the control group, the differences were statistically significant (P<0.05). After treatment, CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in both groups significantly increased, while CD8⁺ level significantly decreased compared with those before treatment; And CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in the observation group were higher than those in the control group, while CD8⁺ was lower than that in the control group, with statistical significance (P<0.05). The rate of repeated abortion in the observation group was lower than that in the control group, and the full-term pregnancy and successful delivery rates were higher than those in control group (P<0.05). The total incidence of complications in the observation group was 11.76%, compared with 7.84% in the control group, there was no significant difference (P>0.05). 【Conclusion】Prednisone and cyclosporin A can effectively regulate sex hormone levels and immune function in RSA patients, improve pregnancy outcomes, and have certain safety.

Key words： Abortion, Habitual Prednisone Cyclosporine Pregnancy Outcome Immunologic Tests

Received: 06 May 2024

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R714.2

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	WU Hong
	LI Honghua

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WU Hong,LI Honghua. Effect of Prednisone and Cyclosporine A on Pregnancy Outcome, Serum Sex Hormone and Immune Function in Treatment of Patients with Recurrent Spontaneous Abortion[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(3): 453-455.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.03.025 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I3/453

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