TLR4与NSE水平对热性惊厥患儿的诊断价值

doi:10.3969/j.issn.1671-7171.2025.03.023

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Abstract 【Objective】 To explore the diagnostic value of Toll-like receptor 4 (TLR4) and neuron-specific enolase (NSE) levels in children with febrile seizures.【Methods】 A total of 72 children with febrile seizures were included in group C, 86 children with fever and infection but no seizures in group B, and 83 healthy children during physical exams in group A. The levels of TLR4 and NSE were measured in all groups. Spearman correlation analysis was used to assess the correlation of febrile seizures with levels of TLR4 and NSE . The diagnostic efficacy of TLR4 and NSE in febrile seizures was analyzed using receiver operating characteristic (ROC) curves.【Results】 The TLR4 and NSE levels in group B and group C were significantly higher than that in group A (P<0.05), with group C showing higher level than group B (P<0.05). Both TLR4 and NSE levels were positively correlated with febrile seizures (P<0.05). The sensitivity of TLR4 and NSE alone and combined detection was 86.1%, 79.2%, and 80.6%, respectively; their specificities were 55.8%, 74.4%, and 88.4%, respectively. And the area under the curve (AUC) was 0.742, 0.832, and 0.911, respectively. Combined detection had better diagnostic value than individual detection (P<0.05).【Conclusion】 Elevated TLR4 and NSE levels in children with febrile seizures are closely associated with the severity. Combined detection of TLR4 and NSE can improve the diagnostic efficiency of febrile seizures and has important clinical significance.

Key words： Seizures, Febrile Toll-Like Receptor 4 Phosphopyruvate Hydratase Diagnosis

Received: 10 December 2024

PACS:

R725

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	DING Jinjin
	ZHAO Caihong
	LIU Youhong

Cite this article:

DING Jinjin,ZHAO Caihong,LIU Youhong. Diagnostic Value of TLR4 and NSE Levels in Children with Febrile Seizures[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(3): 447-449.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.03.023 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I3/447

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