Abstract 【Objective】 To explore the diagnostic value of Toll-like receptor 4 (TLR4) and neuron-specific enolase (NSE) levels in children with febrile seizures.【Methods】 A total of 72 children with febrile seizures were included in group C, 86 children with fever and infection but no seizures in group B, and 83 healthy children during physical exams in group A. The levels of TLR4 and NSE were measured in all groups. Spearman correlation analysis was used to assess the correlation of febrile seizures with levels of TLR4 and NSE . The diagnostic efficacy of TLR4 and NSE in febrile seizures was analyzed using receiver operating characteristic (ROC) curves.【Results】 The TLR4 and NSE levels in group B and group C were significantly higher than that in group A (P<0.05), with group C showing higher level than group B (P<0.05). Both TLR4 and NSE levels were positively correlated with febrile seizures (P<0.05). The sensitivity of TLR4 and NSE alone and combined detection was 86.1%, 79.2%, and 80.6%, respectively; their specificities were 55.8%, 74.4%, and 88.4%, respectively. And the area under the curve (AUC) was 0.742, 0.832, and 0.911, respectively. Combined detection had better diagnostic value than individual detection (P<0.05).【Conclusion】 Elevated TLR4 and NSE levels in children with febrile seizures are closely associated with the severity. Combined detection of TLR4 and NSE can improve the diagnostic efficiency of febrile seizures and has important clinical significance.
DING Jinjin,ZHAO Caihong,LIU Youhong. Diagnostic Value of TLR4 and NSE Levels in Children with Febrile Seizures[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(3): 447-449.
[1] 张建昭,刘子奇,钟倬堂,等.Omicron变异株感染导致儿童热性惊厥的临床特征分析[J].中国当代儿科杂志,2023,25(6):595. [2] 张润春,李树华,王玉珍,等.血清TLR4、TIMP-1水平与小儿热性惊厥临床特征的关系及对继发癫痫的预测价值[J].检验医学与临床,2024,21(14):2089-2093. [3] 刘春子,何帆,刘艳兵,等.高胆红素血症新生儿血清hs-CRP、NSE、B/A值与神经行为能力的关系及对胆红素脑损伤的预测价值[J].江西医药,2024,59(7):672-675. [4] 宋振,张万宏.血清SSA、Aβ及NSE水平与老年颅脑损伤颅骨修补术后早期神经功能恶化的相关性研究[J].实验与检验医学,2024,42(1):93-95. [5] 马占强,李喆,李昭辉,等.复杂性热性惊厥患儿丙二醛、GFAP、NSE表达水平及对脑损伤的预测价值研究[J].临床和实验医学杂志,2024,23(9):983-987. [6] 中华医学会儿科学分会神经学组. 热性惊厥诊断治疗与管理专家共识(2017实用版)[J].中华实用儿科临床杂志,2017,32(18):1379-1382. [7] 乔启程,谭新璐,杨灿,等.热性惊厥与难治性癫痫的相关性研究进展[J].癫痫杂志, 2023, 9(4):330-334. [8] 原子凯,杜丽君,付晓莹,等.儿童热性惊厥/热性惊厥附加症临床特点及其热点基因[J].山西医科大学学报, 2023, 54(1):129. [9] 武文娟,韩伟.白细胞介素-6-572C-G基因多态性与小儿复杂型热性惊厥及症状发作后脑损伤关系临床研究[J].陕西医学杂志,2023,52(10):1371-1374. [10] HALAJIAN E A,LEBLANC E V,GEE K,et al.Activation of TLR4 by viral glycoproteins: a double-edged,sword[J].Front Microbiol,2022,13:1007081. [11] LUO Y H,SHEN G H, WANG G,et al. Upregulations of high,mobility group box l and TLR4/NF-kB signaling path way in hippocampus and serum of rats with febrile seizure[J].Int J Neurosci,2023,4(1):1-9. [12] 田和平,钟琦,王耿焕,等.颅脑损伤后脑脊液中聚集素蛋白与血清NSE及神经功能预后的关系研究[J].浙江医学,2023,45(21):2294-2297. [13] 侯小燕,李欢,高广川.NSE、HMGB1、H2S联合检测在重症热性惊厥伴癫痫患儿中的诊断价值[J].中国急救复苏与灾害医学杂志,2023,18(8):1074-1077. [14] 吴晓燕,黄会芝,王杨,等.血清NSE、HSP70与AEEG在小儿复杂性热性惊厥中的变化及其与继发癫痫的相关性[J].川北医学院学报,2022,37(5):601-605.
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