新生儿真菌性脑膜炎15例临床特点分析<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2025.02.004

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Abstract 【Objective】To explore the clinical characteristics, diagnosis, treatment and prognosis of neonatal fungal meningitis.【Methods】A retrospective analysis was conducted on the clinical data of 15 neonates with fungal meningitis admitted to the Neonatal Department of Hunan Children's Hospital from January 2018 to December 2022. The onset characteristics, clinical manifestations, laboratory tests, treatment and prognosis were summarized.【Results】Among the 15 cases of neonatal fungal meningitis, 11 cases were preterm infants (73.3%), 1 case was extremely low birth weight infant (6.7%), 4 cases were very low birth weight infants (26.7%), and 7 cases were low birth weight infants (46.7%). The age of onset was ≥ 9 days. All 15 cases had received broad-spectrum antibiotics before diagnosis. Twelve cases (80%) received peripherally inserted central catheter (PICC) catheterization, 11 cases (73.3%) received intravenous nutrition, 5 cases (33.3%) received invasive mechanical ventilation, and 10 cases (66.7%) received non-invasive ventilation. Another 5 cases were diagnosed based on positive blood fungal culture and cerebrospinal fluid white blood cell count > 20×10⁶/L. The main treatment was antifungal therapy with fluconazole, amphotericin B, and flucytosine. Eight cases were cured (53.3%), five cases improved (33.3%), and two cases died.【Conclusion】Fungal meningitis in neonates is common in premature infants and low birth weight infants, mainly secondary to the irrational use of broad-spectrum antibiotics and various invasive procedures. The clinical symptoms are similar to those caused by other pathogenic bacteria. Fluconazole can be the first choice for antifungal drugs, and amphotericin B combined with flucytosine can be used when the treatment effect is poor.

Key words： Meningitis, Fungal Infant, Newborn Prognosis

Received: 22 May 2024

PACS:

R725.293

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	LI Ling
	LI Guinan
	WU Yunqin

Cite this article:

LI Ling,LI Guinan,WU Yunqin. Analysis of Clinical Characteristics of 15 Cases of Neonatal Fungal Meningitis[J]. JOURNAL OF CLINICAL RESEARCH, 2025, 42(2): 189-192.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2025.02.004 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2025/V42/I2/189

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