不同剂量右美托咪定联合地佐辛对胸腔镜肺癌根治术患者术后疼痛和认知功能的影响

doi:10.3969/j.issn.1671-7171.2024.12.003

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Abstract 【Objective】 To investigate the effects of different doses of dexmedetomidine (Dex) combined with dezocine on postoperative pain and cognitive function in patients undergoing thoracoscopic lung cancer radical surgery. 【Methods】A total of 122 lung cancer patients were randomly divided into the observation group and the control group, with 61 cases in each group. The observation group received high-dose (1.2 μg/kg) Dex combined with dezocine anesthesia, while the control group received low-dose (0.8 μg/kg) Dex combined with dezocine anesthesia. The hemodynamic levels at different anesthesia time points, postoperative pain responses, levels of inflammatory factors [tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6)] after surgery, postoperative cognitive function, and incidence of adverse reactions were compared between the two groups. 【Results】 At pre-anesthesia (T₀), immediately after endotracheal extubation (T₁), and postoperatively (T₂), there were no statistically significant differences in oxygen saturation (SpO₂) levels between the two groups (P>0.05). At T₁,T₂, both heart rate (HR) and mean arterial pressure (MAP) levels in both groups were lower than at T₀ (P<0.05), and the observation group was lower than the control group (P<0.05). The pain scores at 6 hours and 12 hours postoperatively were lower than at 1 hour postoperatively in both groups (P<0.05), and the pain scores at 12 hours postoperatively were lower than at 6 hours postoperatively (P<0.05). Additionally, the observation group had lower pain scores at 1 hour, 6 hours, and 12 hours postoperatively compared to the control group (P<0.05). Postoperatively, TNF-α and IL-6 levels in both groups were lower than preoperatively (P<0.05), and the observation group was lower than the control group (P<0.05). There were no statistically significant differences in cognitive function scores between the two groups at 72 hours postoperatively compared to preoperatively (P>0.05). Cognitive function levels in both groups were higher at 72 hours postoperatively compared to preoperatively (P<0.05). 【Conclusion】 High-dose Dex combined with dezocine used in anesthesia for thoracoscopic lung cancer radical surgery is more advantageous in reducing postoperative pain levels and inflammation compared to low-dose Dex, minimizing cognitive function impairment with good safety.

Key words： Lung Neoplasms Thoracoscopy Dexmedetomidine Cycloparaffins Pain,Postoperative Cognition

Received: 19 June 2023

PACS:

R734.2

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	YANG Yu
	LIU Min
	ZHU Qinqin

Cite this article:

YANG Yu,LIU Min,ZHU Qinqin. Effects of Different Doses of Dexmedetomidine Combined with Dezocine on Postoperative Pain and Cognitive Function in Patients Undergoing Thoracoscopic Lung Cancer Radical Surgery[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(12): 1833-1835.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.12.003 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I12/1833

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