特发性高钙尿症患儿血清PTH、25(OH)D水平与尿红细胞、尿钙的相关性分析

doi:10.3969/j.issn.1671-7171.2024.11.031

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1211 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the correlation of serum parathyroid hormone (PTH), 25-hydroxyvitamin D[25(OH)D], calcium and phosphorus levels with urinary red blood cells and urinary calcium at 24 h in children with idiopathic hypercalcemia.【Methods】A total of 26 children with idiopathic hypercalcemia admitted to our hospital from January 2019 to December 2023 (the observation group) were selected, and 33 healthy volunteers who underwent physical examination in our hospital were selected as the control group. The serum levels of PTH, 25(OH)D, phosphorus and calcium were compared between the two groups, and the correlation between urinary red blood cells and 24 h urinary calcium levels and serum PTH, 25(OH)D, phosphorus and calcium levels in the observation group was analyzed.【Results】The levels of serum PTH and 25(OH)D in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in serum phosphorus and calcium levels between the two groups (P>0.05). Pearson correlation analysis showed that PTH level in the observation group was positively correlated with urinary red blood cells and 24 h urinary calcium (r=0.877, 0.717, P<0.01). Serum 25(OH)D levels were positively correlated with urinary red blood cells and 24 h urinary calcium (r=0.837, 0.746, P<0.01). There was no correlation between serum phosphorus and urinary red blood cells and urinary calcium at 24 h (P>0.05). There was no correlation between serum calcium and urinary red blood cells and urinary calcium at 24 h (P>0.05).【Conclusion】The serum levels of PTH and 25(OH)D were significantly increased in children with idiopathic hypercalcemia, which was positively correlated with urinary calcium and hematuria.

Key words： Hypercalciuria Parathyroid Hormone/BL Calcifediol/BL Calcium/BL Phosphorus/BL Child

Received: 10 September 2024

PACS:

R726.96

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CHEN Shanya
	XUN Mai

Cite this article:

CHEN Shanya,XUN Mai. Correlation Analysis of Serum PTH, 25(OH)D Levels with Urinary Red Blood Cells and Urinary Calcium in Children with Idiopathic Hypercalcemia[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(11): 1740-1742.

URL:

http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.11.031 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I11/1740

[1] GARCÍA NIETO V M, LUIS YANES M I, CARREÑO P T, et al. The idiopathic hypercalciuria reviewed. Metabolic abnormality or disease?[J].Nefrologia (Engl Ed),2019,39(6):592-602.
[2] OLEFIR Y V, YAVORSKII A N, BUTNARU D V. Idiopathic hypercalciuria. Diagnosis and treatment[J].Urologiia,2017(6):112-119.
[3] 张思伟,王毅明,游玉梅.特发性高尿钙症对病人骨密度及骨代谢指标的影响[J].中国临床医学影像杂志,2009,20(8):607-610.
[4] MAITI A, BECKMAN M J. Extracellular calcium is a direct effecter of VDR levels in proximal tubule epithelial cells that counter-balances effects of PTH on renal vitamin D metabolism[J].J Steroid Biochem Mol Biol,2007,103(3-5):504-508.
[5] ALRIGHT F,HERMEMAN P,BENEDICT P H,et al.Idiopathic hypercalciuria:a prehminary report[J].Proc R Soc Med,1953,46(12):1077-1081.
[6] 刘艳,张碧丽.特发性高钙尿症研究新进展[J].医学综述,2010,16(19):2969-2972.
[7] 刘亚琼,余静,何晓芸,等.21例特发性高钙尿症临床分析[J].临床医学,2007,27(8):47.
[8] DHAYAT N A, MATTMANN C, SEEGER H, et al. The Vitamin D metabolite diagnostic ratio associates with phenotypic traits of idiopathic hypercalciuria[J].Kidney Int Rep,2024,9(4):1072-1082.
[9] MAGGIO A J, COBURN J W, BROSMAN S A, et al. The role of vitamin D in idiopathic hypercalciuria[J].J Urol,1979,122(2):147-151.
[10] KULDA V. Vitamin D metabolism[J].Vnitr Lek,2012,58(5):400-404.
[11] HADDAD J G. Vitamin D binding proteins[J].Adv Nutr Res,1982,4:35-58.
[12] CHEN T H, WANG Y, HAO Z W, et al. Parathyroid hormone and its related peptides in bone metabolism[J].Biochem Pharmacol,2021,192:114669.
[13] ARNAUD C D, TENENHOUSE A M, RASMUSSEN H, et al. Parathyroid hormone[J].Annu Rev Physiol,1967,29:349-372.
[14] WATSON H, HANLEY D A. Parathyroid hormone: regulation of synthesis and secretion[J].Clin Invest Med,1993,16(1):58-77.
[15] CHESNEY R W. Interactions of vitamin D and the proximal tubule[J].Pediatr Nephrol,2016,31(1):7-14.
[16] JOHNSON J A, KUMAR R. Vitamin D and renal calcium transport[J].Curr Opin Nephrol Hypertens,1994,3(4):424-429.
[17] ASSIMOS D G. Re: evidence for increased renal tubule and parathyroid gland sensitivity to serum calcium in human idiopathic hypercalciuria[J].J Urol,2014,191(3):678-679.
[18] ALEXANDER R T, DIMKE H. Effects of parathyroid hormone on renal tubular calcium and phosphate handling[J].Acta Physiol (Oxf),2023,238(1):e13959.