超声造影联合细针穿刺活检对TI-RADS 4类甲状腺结节的诊断及结节性质与FPG、HbA1c水平的相关性分析<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2024.09.011

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Abstract 【Objective】To explore the diagnostic efficacy of contrast-enhanced ultrasound combined with fine-needle aspiration biopsy for TI-RADS 4 thyroid nodules, and investigate its association with levels of FPG and HbA1c. 【Methods】A total of 351 patients with TI-RADS 4 nodules from July 2019 to July 2023 were selected and divided into a malignant group (n=194) and a benign group (n=157) according to the pathological results. All patients underwent contrast-enhanced ultrasonography and fine-needle aspiration biopsy. The levels of serum FPG, HbA1c, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were compared between the two groups of patients, and the diagnostic effect of ultrasound contrast-enhanced imaging combined with fine needle aspiration biopsy on TI-RADS 4 thyroid nodules and its correlation with FPG and HbA1c levels were analyzed.【Results】The sensitivity of ultrasound contrast examination was 84.3%, the specificity was 85.6%, the accuracy was 85.4%, the positive predictive value was 95.5%, and the negative predictive value was 62.4%. The sensitivity of ultrasound contrast combined with fine needle aspiration biopsy nodules (the combined examination) was 95.4%, the specificity was 87.9%, the accuracy was 93.2%, the positive predictive value was 95.6%, and the negative predictive value was 85.6%. The sensitivity, accuracy and negative predictive value of the combined examination were higher than those of ultrasound contrast examination alone, and the difference was statistically significant (P<0.05). The serum FPG and HbA1c levels in the malignant group were higher than those in the benign group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the serum LDL-C, HDL-C, TG, and TC levels between the two groups (P> 0.05). Pearson correlation analysis showed that TI-RADS 4 thyroid nodules were positively correlated with the patients' serum HbA1c and FPG levels (r=0.821, 0.800, both P<0.05).【Conclusion】 Ultrasound contrast imaging combined with fine needle aspiration biopsy has high diagnostic value for TI-RADS 4 nodules. The characteristic of the thyroid nodules is correlated with the patient's serum FPG and HbA1c levels.

Key words： Thyroid Nodule/DG Ultrasonography, Interventional Biopsy, Fine-Needle Glycated Hemoglobin A Blood Glucose

Received: 16 November 2023

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	LI Jinsong
	TIAN Xiuli

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LI Jinsong,TIAN Xiuli. Contrast-Enhanced Ultrasonography Combined with Fine-Needle Aspiration Biopsy in Diagnosing TI-RADS 4 Thyroid Nodule and its Correlation with FPG and HbA1c Levels[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(9): 1319-1321.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.09.011 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I9/1319

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