GTP酶激活蛋白SH3功能区结合蛋白1在非小细胞肺癌中的表达及其与放疗疗效的关系

doi:10.3969/j.issn.1671-7171.2024.07.017

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Abstract 【Objective】To investigate the expression of GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) in tissues of patients with non-small cell lung cancer (NSCLC) and its relationship with the efficacy of radiotherapy. 【Methods】The expression levels of G3BP1 protein were measured in the tissues of 133 NSCLC patients. The relationship between G3BP1 expression and NSCLC clinicopathological parameters as well as radiotherapy efficacy was analyzed. 【Results】There were statistically significant differences in G3BP1 protein levels among NSCLC tissues with different tumor diameters, TNM stages, and lymph node metastasis (P<0.05). The G3BP1 protein level in the radiotherapy effective group was lower than that in the ineffective group, with a statistically significant difference (P<0.05). The area under the receiver operating characteristic (ROC) curve (AUC) for evaluating the efficacy of G3BP1, optimal cutoff point, sensitivity, and specificity were 0.802, 2.33, 86.54%, and 61.73%, respectively. Logistic multivariate regression analysis showed that tumor diameter, TNM stage, lymph node metastasis, acute radiation pneumonitis, and G3BP1 level were independent risk factors affecting the efficacy of radiotherapy in NSCLC (P<0.05). 【Conclusion】G3BP1 is related to tumor diameter, TNM stage, and lymph node metastasis in NSCLC. Its level can provide a reference for evaluating the efficacy of radiotherapy in patients.

Key words： Carcinoma, Non-Small-Cell Lung GTPase-Activating Proteins Carrier Proteins

Received: 23 August 2023

PACS:

R734.2

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	WANG Long
	CHEN Yu
	ZHAO Ke

Cite this article:

WANG Long,CHEN Yu,ZHAO Ke. Relationship of GTPase-Activating Protein SH3 Domain-Binding Protein 1 Expression in Non-Small Cell Lung Cancer with Radiotherapy Efficacy[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(7): 1020-1023.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.07.017 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I7/1020

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