右美托咪定复合丙泊酚对胆囊结石手术患者的麻醉效果及认知功能的影响

doi:10.3969/j.issn.1671-7171.2024.06.025

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Abstract 【Objective】To investigate the anesthetic effect and cognitive function impact of dexmedetomidine(Dex) combined with propofol anesthesia in patients undergoing gallstone surgery. 【Methods】A total of 160 patients with gallstones were randomly divided into the observation group and the control group, with 80 cases in each group. Both groups underwent laparoscopic cholecystectomy(LC). Patients in the control group received intravenous propofol anesthesia, while the observation group received Dex combined with propofol anesthesia. Surgical-related indicators, hemodynamic parameters before anesthesia and after extubation [mean arterial pressure(MAP), heart rate(HR), and oxygen saturation(SpO₂)], intraoperative dosages of remifentanil and propofol, mental state, pain scores, and the occurrence of adverse reactions were compared between the two groups. 【Results】There were no significant differences in surgical time and intraoperative blood loss between the two groups(P>0.05). The onset time of anesthesia, anesthesia recovery time, and recovery time of spontaneous breathing in the observation group were significantly shorter than those in the control group(P<0.05). The MAP and HR levels of both groups after extubation were lower than before anesthesia, and SpO₂ level was higher than before anesthesia(P<0.05). Moreover, the MAP and SpO₂ of the observation group were higher than those of the control group, while HR was lower than the control group(P<0.05). The dosages of remifentanil and propofol in the observation group were lower than those in the control group(P<0.05). The Mini-Mental State Examination(MMSE) and Visual Analog Scale(VAS) scores at 2 hours post-operation were significantly lower than at 6 hours post-operation in both groups(P<0.05). The MMSE scores at 2 hours and 6 hours post-operation in the observation group were higher than those in the control group, while the VAS scores were lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). 【Conclusion】 The combination of Dex and propofol for LC provides significant analgesic effects, characterized by rapid onset, recovery, and spontaneous breathing recovery. It can reduce the dosage of anesthetic drugs, maintain hemodynamic stability, and have a minimal impact on postoperative cognitive function. It is safe.

Key words： Cholecystolithiasis/SU Dexmedetomidine/PD Propofol/PD Anesthesia

Received: 26 August 2023

PACS:

R575.621

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	LYU Xueliang
	JIANG Peng
	LI Xianhu

Cite this article:

LYU Xueliang,JIANG Peng,LI Xianhu. The Anesthetic Effect and Cognitive Function Impact of Dexmedetomidine Combined with Propofol in Patients Undergoing Gallstone Surgery[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(6): 889-892.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.06.025 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I6/889

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