Abstract 【Objective】To investigate the clinical efficacy of Guizhi Gancao Decoction Combined with conventional western medicine in the treatment of patients with chronic heart failure. 【Methods】A total of 102 patients with chronic heart failure were selected and divided into observation group and control group according to the random number table method, with 51 cases in each group. The control group was treated with conventional western medicine, and the observation group was treated with Guizhi Gancao Decoction on the basis of the control group. After one month of treatment, the clinical efficacy, the occurrence of adverse reactions, and the laboratory indexes [high-sensitivity C-reactive protein (hs-CRP), N-terminal pro brain natriuretic peptide (NT-proBNP), red blood cell distribution width (RDW)], TCM syndrome score, and cardiac function indexes [left ventricular end diastolic internal diameter (LVEDD), left ventricular end systolic diameter (LVESD), and left ventricular ejection fraction (LVEF)] before and after treatment were compared between the two groups. 【Results】The total effective rate of the observation group was higher than the control group, and the difference was statistically significant (P<0.05). After treatment, the scores of shortness of breath, palpitation, cough, expectoration, and less breath and lazy words in the two groups were lower than those before treatment, and the observation group was lower than that in the control group, the difference was statistically significant (P<0.05); The levels of NT-proBNP, hs-CRP and RDW in the observation group were significantly lower than those before treatment and after treatment in the control group (P<0.05); LVEDD and LVESD of the two groups were lower than before treatment, LVEF was higher than before treatment, LVEDD and LVESD of the observation group were lower than those of the control group, LVEF was higher than that of the control group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】On the basis of conventional western medicine treatment, the application of Guizhi Gancao Decoction in the treatment of chronic heart failure can improve the clinical treatment effect,improve cardiac function, with high safety, which is worthy of clinical application.
ZHAO Lichen. Clinical Efficacy of Guizhi Gancao Decoction Combined with Conventional Western Medicine in the Treatment of Patients with Chronic Heart Failure[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(4): 579-582.
[1] CAMPBELL C M, KAHWASH R, ABRAHAM W T. Optimizer Smart in the treatment of moderate-to-severe chronic heart failure[J].Future Cardiol,2020,16(1):13-25. [2] FREA S, PIDELLO S, VOLPE A, et al. Diuretic treatment in high-risk acute decompensation of advanced chronic heart failure-bolus intermittent vs. continuous infusion of furosemide: a randomized controlled trial[J].Clin Res Cardiol,2020,109(4):417-425. [3] WANG Y, WANG Q, LI C, et al. A Review of Chinese Herbal Medicine for the Treatment of Chronic Heart Failure[J].Curr Pharm Des,2017,23(34):5115-5124. [4] 周云洁,高原,宋歌. 桂枝甘草汤联合曲美他嗪对慢性心力衰竭患者的临床疗效[J].中成药,2020,42(5):1187-1191. [5] 杨杰孚,王华,柴坷.2018中国心力衰竭诊断和治疗指南亮点[J].中国心血管病研究,2018,16(12):1057-1060. [6] 中国中西医结合学会心血管疾病专业委员会,中国医师协会中西医结合医师分会心血管疾病专业委员会. 慢性心力衰竭中西医结合诊疗专家共识[J].心脑血管病防治,2016,16(5):340. [7] 李海良,张克清. 参芪复脉汤联合西药治疗慢性心衰疗效及对患者心功能的影响[J].陕西中医,2019,40(2):163-166. [8] NORDFONN O K, MORKEN I M, BRU L E, et al. Burden of treatment in patients with chronic heart failure: a cross sectional study[J].Heart Lung,2021,50(3):369-374. [9] 向越,付晓星.真武汤合血府逐瘀汤对慢性心衰患者心功能及心室重构的影响[J].医学临床研究,2022,39(9):1303-1305. [10] GUO B, YANG T, NAN J, et al. Efficacy and safety of Shenfu injection combined with sodium nitroprusside in the treatment of chronic heart failure in patients with coronary heart disease: a protocol of randomized controlled trial[J].Medicine (Baltimore),2021,100(7): e24414. [11] 刘海明. 真武汤合桂枝甘草汤治疗慢性心力衰竭临床研究[J].四川中医,2016,34(12):62-65. [12] 桑岚. 桂枝甘草龙骨牡蛎加味汤治疗冠状动脉粥样硬化性心脏病室性早搏40例临床评价[J].中国药业,2017,26(18):40-42. [13] 苏伟江,赖木乔,王李娟. 厄贝沙坦联合美托洛尔对慢性心衰患者的疗效和血清hs-CRP、NT-proBNP水平的影响[J].广州医科大学学报,2019,47(5):17-20. [14] FARNSWORTH C W, BAILEY A L, JAFFE A S, et al. Diagnostic concordance between NT-proBNP and BNP for suspected heart failure[J].Clin Biochem,2018,59(1):50-55. [15] LIPPI G, TURCATO G, CERVELLIN G, et al. Red blood cell distribution width in heart failure: A narrative review[J].World J Cardiol,2018,10(2):6-14. [16] 李白雪,黎桂玉,彭杨芷,等. 苓桂术甘汤对肺动脉高压致右心衰大鼠心功能、神经内分泌因子水平及心脏组织NF-κB蛋白表达的影响[J].成都中医药大学学报,2021,44(2):31-36.
2024, Vol. 41 
