重组人干扰素α2b凝胶联合阿奇霉素治疗慢性宫颈炎伴HPV感染患者的临床疗效

doi:10.3969/j.issn.1671-7171.2024.04.026

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Abstract 【Objective】To explore the application effect of recombinant human interferon α2b gel combined with azithromycin in patients with chronic cervicitis with HPV infection. 【Methods】A total of 110 patients with chronic cervicitis with HPV infection who were admitted to the XD Group Hospital from March 2021 to March 2023 were selected as the research objects. They were divided into the control group and the observation group by random number table method, with 55 cases in each group. The control group was treated with recombinant human interferon α2b gel, while the observation group was treated with recombinant human interferon α2b gel combined with azithromycin. Both treatments were for a course of 2 weeks. The clinical efficacy, Lactobacillus reduction rate, leukocyte esterase (LE) test and coagulase (GADP), vaginal pH value, inflammation factors [tumor necrosis factor-α (TNF-α), interleukin-1β(IL-1β), interleukin-8(IL-8)]level, HPV virus load, conversion rate, and recurrence rate of the two groups were compared. 【Results】The total effective rate of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). The reduction rate of Lactobacillus, positive rate of LE, positive rate of GADP, and proportion of vaginal pH value >4.5 in the observation group were all higher than those in the control group, and the differences were statistically significant (P<0.05). Before treatment, there was no statistical significance in the comparison of inflammation factors between the two groups (P>0.05). After treatment, the levels of TNF-α, IL-1β, and IL-8 in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05). After treatment, the virus load of both groups decreased, while the virus load of the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05). The HPV negative conversion rate of the observation group was higher than that of the control group, the HPV recurrence rate and the disease recurrence rate in the observation were lower than those in the control group, and the differences were statistically significant (P<0.05). 【Conclusion】Recombinant human interferon α2b gel combined with azithromycin has significant effects in patients with chronic cervicitis with HPV infection. It can reduce inflammation, reduce HPV virus load, promote HPV negative conversion, which is worth promoting.

Key words： Uterine Cervicitis/DT Papillomavirus Infections/DT Interferon alpha-2 Azithromycin

Received: 30 June 2023

PACS:

R711.32

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	XIE Fei
	LI Shuang

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XIE Fei,LI Shuang. Effects of Using Recombinant Human Interferon α2b Gel in Combination with Azithromycin in Patients with Chronic Cervicitis Accompanied by HPV Infection[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(4): 572-575.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.04.026 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I4/572

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