Abstract 【Objective】To explore the analgesic effect and safety of Sufentanil combined with Parecoxib Sodium in secondary cesarean section. 【Methods】A total of 94 parturients scheduled for secondary cesarean section were randomly divided into an observation group and a control group, with 47 cases in each. The control group received Sufentanil for analgesia, while the observation group was given a combination of Sufentanil and Parecoxib Sodium for pain relief. Perioperative parameters of both groups were compared, including operation time, blood loss, fluid replenishment, and oxytocic types. The Visual Analog Scale (VAS) was used to assess and compare the pain level of the parturients in both groups at 3 min (T1), 5 min (T2), 10 min (T3), 20 min (T4), 30 min (T5) post-analgesia, and at the end of surgery (T6). Hemodynamic parameters [oxygen saturation (SPO2), heart rate (HR), respiratory rate (RR)] were monitored and compared at 1 h, 6 h, 24 h, and 48 h postoperatively. Adverse reactions during the medication period were calculated. 【Results】There were no significant differences in operation time, blood loss, fluid replenishment, and oxytocic types between the observation and the control groups (P>0.05). At T1, T2, T3, T4, T5, T6, the VAS scores of the observation group were significantly lower than those of the control group (P<0.05). At 1 h, 6 h, 24 h, and 48 h postoperatively, there were no significant differences in SPO2, HR, and RR levels between the observation and control groups (P>0.05). The incidence of adverse reactions was not significantly different between the two groups (P>0.05). 【Conclusion】The analgesic effect of Sufentanil combined with Parecoxib Sodium in secondary cesarean section is superior to that of Sufentanil alone. It can maintain stable hemodynamics and has a high safety profile, making it clinically valuable.
JIANG Xiangrong,HU Yanmei. Analgesic Efficacy and Safety of Sufentanil Combined with Parecoxib Sodium for Secondary Cesarean Section[J]. JOURNAL OF CLINICAL RESEARCH, 2024, 41(4): 548-550.
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2024, Vol. 41 
