血清TNC、血压及空腹血糖与糖尿病周围神经病变及增殖性糖尿病视网膜病变的相关性<sup>*</sup>

doi:10.3969/j.issn.1671-7171.2024.03.002

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Abstract 【Objective】To investigate the relationship of serum tenascin-C(TNC), blood pressure and blood glucose with diabetic peripheral neuropathy(DPN) and Proliferative diabetic retinopathy(PDR). 【Methods】A total of 122 patients with type 2 diabetes(T2DM) admitted to Liuzhou Red Cross Hospital from June 2021 to June 2022 were selected and divided into group A(patients without DPN, n=75) and group B(patients with DPN, n=47) according to whether they had DPN or not. Group A and group B were further divided two sub-groups according to whether PDR was present. Group A was divided into group A1(patients without PDR, n=23) and group A2(patients with PDR, n=52), and group B was divided into group B1(patients without PDR, n=31) and group B2(patients with PDR, n=16). Serum TNC was detected by enzyme-linked immunoassay(ELISA), Fasting blood glucose(FPG) was measured by Roche biochemical analyzer, and blood pressure was measured in each group. 【Results】There were no significant differences in serum TNC, FPG and systolic pressure(SBP) between group A and group B(all P>0.05). There was significant difference in diastolic pressure(DBP) between group A and group B(P<0.05). There were no significant differences in serum TNC levels, SBP and DBP values between group A1 and group A2,as well as between group B1 and group B2(all P>0.05). There was no significant difference in serum FPG level between group A1 and group A2(P>0.05), but there was significant difference in serum FPG level between B1 and B2 groups(P<0.05). There was no correlation of DPN with TNC, SBP and DBP(P>0.05), but there was a positive correlation between DPN and FPG(P<0.05).【Conclusion】Serum TNC level is not associated with DPN, PDR or DPN with PDR. Patients with DPN had higher blood pressure than those without DPN, and patients with both DPN and PDR had higher FPG than those with DPN and PDR alone. Clinicians should control blood pressure and blood sugar levels in patients with T2DM to reduce the incidence of T2DM complications.Clinicians should pay attention to timely treatment and control of blood pressure and blood sugar in T2DM patients to reduce the occurrence of T2DM complications.

Key words： Diabetic Neuropathies/CO Diabetic Retinopathy/CO Diabetes Mellitus, Type 2/CO Tenascin/BL Blood Pressure Blood Glucose

Received: 12 October 2023

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R587.1

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2024.03.002 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2024/V41/I3/325

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