甲苯磺酸瑞马唑仑在儿童小肠镜检查麻醉中的应用价值

doi:10.3969/j.issn.1671-7171.2023.09.003

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Abstract 【Objective】To explore the clinical effect of remimazolam toluenesulfonate in anesthesia for small intestinal endoscopy in children.【Methods】A total of 98 children who underwent small intestinal endoscopy under general anesthesia and were admitted to our hospital from April 2022 to December 2022 were randomly divided into a propofol group (P group) and a remimazolam toluenesulfonate group (R group) using a random number table method,with 49 cases in each group. We compared the success rates of anesthesia induction,anesthesia maintenance,and the time of consciousness disappearance between the two groups; Compare the heart rate (HR),systolic blood pressure (SBP),diastolic blood pressure (DBP),and blood oxygen saturation (SPO₂) of two groups of children at rest (T₀),1 minute after administration (T₁),2 minutes after administration (T₂),after tracheal intubation (T₃),at the end of surgery (T₄),and at PACU (T₅); Two groups of perioperative related indicators,adverse reactions,and postoperative behavioral changes were also compared.【Results】The onset time of sedation in the Group R was significantly longer than that in the Group P,with a statistically significant difference (P<0.05). At T₁,T₂,T₃,T₄,and T₅,the HR,SBP,and DBP of the two groups of children were significantly lower than those at T₀ (P<0.05); At T₁,T₂,and T₅,the SPO₂ of the two groups of children was significantly lower than at T₀ (P<0.05). At T₁ and T₂,the HR,SBP,DBP,and SPO₂ levels in the Group R were higher than those in the Group P (P<0.05). The awakening time of the Group R was shorter than that of the Group P,and the difference was statistically significant (P<0.05). The incidence of perioperative hypotension,bradycardia,respiratory depression,and injection pain in the Group R was lower than that in the Group P,and the difference was statistically significant (P<0.05); There was no statistically significant difference in postoperative PHBQ-AS scores between the two groups (P>0.05).【Conclusion】Remimazolam toluenesulfonate is safe and effective in general anesthesia for small intestinal endoscopy in children,and the incidence of adverse reactions is low,which is worthy of clinical reference.

Key words： Remimazolam Intestine,Small Endoscopy Anesthesia Child

Received: 23 March 2023

PACS:

R656.9

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	WEI Siwei
	WU Lei
	XIANG Zhen
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Cite this article:

WEI Siwei,WU Lei,XIANG Zhen, et al. Application of Remimazolam Toluenesulfonate in Anesthesia for Small Intestinoscopy in Children[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(9): 1288-1291.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.09.003 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I9/1288

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