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| Correlation Analysis of Serum Immunoglobulin,C3 and C4 Levels with Prognosis of Patients with Hypertensive Intracerebral Hemorrhage |
| CHEN Hong-nan, XI Feng-yu, ZHANG Yun, et al |
| Shaanxi Provincial People's Hospital,Xi'an Shaanxi 710068 |
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Abstract 【Objective】 To investigate the relationship of serum immunoglobulin,C3 and C4 levels with the prognosis of patients with hypertensive intracerebral hemorrhage (HICH). 【Methods】 A total of 114 patients with HICH in our hospital from January 2018 to May 2021 were selected as the control group. In the same period,67 hypertensive patients with good blood pressure were enrolled in the control group. The levels of serum immunoglobulin (IgG,IgA),C3,and C4 were compared between the control group on the day of admission and the observation group before operation and after operation. According to the prognosis of the observation group,patients were divided into the good prognosis group and the poor prognosis group. The levels of serum immunoglobulin,C3,and C4 in patients with different prognosis were compared 7 days after operation. Spearman rank correlation model and COX stepwise regression model were used to analyze the correlation between levels of serum immunoglobulin,C3,C4 with the prognosis of patients. 【Results】 Serum IgG,IgA levels and preoperative C3,C4 levels in the observation group were lower than those in the control group on 1 day,3 days,7 days,and 14 days after operation (P<0.05); The level of C3 and C4 showed a decreasing trend,and the levels of C3 and C4 showed a rising trend,and the difference was statistically significant (P<0.05). The serum IgG and IgA levels of patients in the good prognosis group were higher than those of patients in the poor prognosis group,while the levels of C3 and C4 in the good prognosis group were lower than those of patients in the poor prognosis group (P<0.05). Spearman rank correlation analysis showed that serum IgG and IgA levels 7 days after surgery were positively correlated with prognosis,and C3 and C4 levels were negatively correlated with prognosis. COX stepwise regression model analysis showed that serum IgG,IgA,C3,and C4 levels 7 days after operation were the relevant factors affecting prognosis (P<0.05).【Conclusion】 The levels of serum immunoglobulin,C3 and C4 are significantly correlated with the prognosis of patients with HICH. Dynamic monitoring of the changes of serum immunoglobulin,C3 and C4 levels is helpful to guide the clinical treatment.
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Received: 11 April 2022
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[1] 王鲜茹,肖铮铮,耿晓平,等.高血压脑出血患者医院感染的病原学特点及危险因素分析[J].中华医院感染学杂志,2017,27(11):2461-2464.
[2] 孙树凯,张百平,贾栋.小骨窗开颅内镜辅助血肿清除治疗高血压脑出血效果分析[J].临床外科杂志,2018,26(12):970-972.
[3] 付如意,毛露,孙硕,等.脑缺血再灌注后免疫损伤分子机制研究进展[J].中风与神经疾病杂志,2019,36(9):852-854.
[4] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国脑出血诊治指南(2019)[J].中华神经科杂志,2019,52(12):994-1005.
[5] 张海涛.高血压性脑出血开颅手术与微创引流治疗的比较[J].山西医药杂志,2017,46(14):1729-1730.
[6] 陶海泉.高压氧治疗对高血压性脑出血患者血清神经元特异性烯醇化酶、转化生长因子β1、血管内皮功能及免疫功能的影响[J].国际免疫学杂志,2017,40(4):391-395.
[7] 叶路,战丽,贺智,等.创伤后的免疫变化和免疫支持[J].中国急救复苏与灾害医学杂志,2010,5(5):462-463.
[8] 王锐,尹路路,苏成洋,等.创伤后免疫抑制的研究进展[J].医学综述,2017,23(6):1095-1099.
[9] 丁美兰,杜宁娜,李红梅.早期肠内-肠外联合营养对高血压脑出血患者术后免疫功能及预后的影响[J].医学临床研究,2018,35(12):2377-2379.
[10] 刘瑞东,周忆频.肠内营养时机对老年重型颅脑疾病术后临床疗效的影响[J].天津医药, 2014,42(11):1106-1108.
[11] 郭玉臣,徐兆冰,徐印符,等.微骨窗入路对高血压脑出血的临床疗效细胞免疫及预后影响[J].中国实用神经疾病杂志,2017,20(15):97-98.
[12] 陈文洁.高血压脑出血患者血清补体C3、C4与免疫球蛋白水平检测的临床意义[J].湖北民族大学学报(医学版),2021,38(4):83-85.
[13] 徐兵,雍成明,杨代明.高血压性脑出血手术预后的影响因素分析[J].中国临床神经外科杂志,2018,23(10):662-664. |
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2023, Vol. 40 
