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| Efficacy of Maintenance Therapy with Low Dose of Apatinib after TACE for Primary Liver Cancer |
| GAO Meng-jia, WANG Yu, GUO Wen-wei, et al |
| Ankang Central Hospital,Ankang Shaanxi 725000 |
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Abstract 【Objective】 To investigate the clinical effect of maintenance therapy with low dose of apatinib after transcatheter arterial chemoembolization (TACE) for primary liver cancer. 【Methods】 A total of 90 patients with primary liver cancer in our hospital were randomly divided into the observation group and the control group with 45 cases each. Patients in both groups were treated with TACE,while the patients in the observation group received 250 mg of apatinib maintenance treatment after TACE. T lymphocyte subsets (CD3+,CD4+,CD8+,CD4+/CD8+) on 1 day before surgery and 4 weeks post-TACE,tumor objective response rate (ORR),progression-free survival,total survival and adverse reactions after 1,3,6 and 12 months of treatment were compared between the two groups. 【Results】 Four weeks after treatment,CD3+,CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group,and CD8+ was lower than that in the control group. The differences were statistically significant (all P<0.05). After 6 and 12 months of treatment,the ORR rate of the observation group was higher than that of the control group,and the difference was statistically significant (all P<0.05). The progression-free survival period was 6.6 months in the control group and 11.9 months in the observation group; The total survival period of the control group was 5.1 months,while the progression-free survival period of the observation group was 9.8 months; Kaplan-Meier method and Log-rank test showed that the progression-free survival and total survival of the observation group were longer than those of the control group,and the difference was statistically significant (both P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 The effect of maintenance therapy with low dose of apatinib after TACE for primary liver cancer is significant,which can improve the tumor remission rate and the immune function of patients,improve the progression-free survival and total survival,while the adverse reactions are controllable.
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Received: 24 April 2022
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2023, Vol. 40 
