|
|
|
| Effects of Alprostadil on Continuous Renal Replacement Therapy and Oxidative Stress in Acute Renal Failure Patients with Diabetic Nephropathy |
| HE Juan, ZHU Hui-rong, ZHAO Jin |
| Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200000 |
|
|
|
|
Abstract 【Objective】 To investigate the effect of alprostadil on continuous renal replacement therapy(CRRT) and oxidative stress in acute renal failure patients with diabetic nephropathy(DN). 【Methods】 A total of 104 patients with acute renal failure with DN were randomly divided into the observation group and the control group The control group was treated with CRRT,while the observation group was additionally treated with alprostadil on the basis of the control group. The clinical efficacy,reactive oxygen species (ROS),superoxide dismutase (SOD),urinary albumin excretion rate (UAER),8-hydroxydeoxyguanine (8-OHdG),β2 microglobulin (β2-MG),endothelin-1 (ET-1),von Willebrand factor (vWF) levels and adverse reactions were compared between the two groups. 【Results】 The total effective rate of the observation group was higher than that of the control group (P<0.05). After treatment,the levels of ROS,SOD,8-OHdG,UAER,β2-MG and vWF in both groups were lower than those before treatment (P<0.05); And the parameters in the observation group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions in both groups (P>0.05). 【Conclusion】 The use of alprostadil with CRRT in acute renal failure patients with diabetic nephropathy can improve clinical efficacy,reduce oxidative stress,improve renal function,and have a certain protective effect on vascular endothelium.
|
|
Received: 20 June 2022
|
|
|
|
|
|
[1] XIONG Y B.The signaling of cellular senescence in diabetic nephropathy[J].Oxid Med Cell Longev,2019,19(1):94-100.
[2] STEFAN G,STANCU S,ZUGRAVU A,et al. Histologic predictors of renal outcome in diabetic nephropathy:Beyond renal pathology society classification [J].Medicine (Baltimore),2019,98(27):1633-1670.
[3] ANTLANGER M,NOORDZIJ M,van de LUIJTGAARDEN M,et al. Sex differences in kidney replacement therapy initiation and maintenance [J].Clin J Am Soc Nephrol,2019,14(11):1616-1625.
[4] SUGIYAMA T,OBA K,KOBAYASHI Y. Risk-stratified incidence of renal replacement therapy initiation:a longitudinal analysis using medical claims and health checkup data [J].Tohoku J Exp Med,2019,248(2):125-135.
[5] LIU D L,GAO F,LI L,et al. The prophylactic effect of alprostadil on contrast-induced nephropathy in renal insufficiency patients after percutaneous coronary intervention [J].Am J Transl Res,2021,13(4):3766-3772.
[6] 中华医学会糖尿病学分会微血管并发症学组. 中国糖尿病肾脏疾病防治临床指南[J].中华糖尿病杂志,2019,11(1):15-28.
[7] 赵慧萍,王梅. 2014年《急性肾衰竭的腹膜透析治疗》指南(成人部分)解读[J].中国血液净化,2015,14(7):395-399.
[8] 杜兴旭,赵维彦. 糖尿病肾病的诊断和治疗[M]. 长春:吉林科学技术出版社,2012:84-85.
[9] ANDERSON A H,XIE D W,WANG X,et al. Novel risk factors for progression of diabetic and nondiabetic CKD:findings from the chronic renal insufficiency cohort (CRIC) study [J].Am J Kidney Dis,2021,77(1):56-73.
[10] 韩瑞萍,袁光新,陈慰,等.连续性肾脏替代治疗急性肾功能衰竭疗效及对T淋巴细胞炎症因子和血清电解质水平的影响[J].河北医学,2021,27(8):1312-1316.
[11] SCHRAUBEN S J,SHOU H C,ZHANG X M,et al. Association of multiple plasma biomarker concentrations with progression of prevalent diabetic kidney disease:findings from the chronic renal insufficiency cohort (CRIC) study [J].J Am Soc Nephrol,2021,32(1):115-126.
[12] 黄秀丽,吴艳,喻荷淋,等. 替米沙坦联合前列地尔对糖尿病肾病氧化应激、免疫炎性反应及肾功能的影响[J].疑难病杂志,2020,19(7):705-708.
[13] JIA Y,LIU L L,SU J L,et al. Effect of alprostadil in the treatment of intensive care unit patients with acute renal injury [J].World J Clin Cases,2021,9(6):1284-1292.
[14] 郭丽芳,孟皓波,高爱华,等. 不同分期的糖尿病肾病病人炎性因子及氧化应激指标的变化及意义研究[J].内蒙古医科大学学报,2019,41(4):370-373.
[15] O'NEILL R A,GALLAGHER P,DOUGLAS T,et al. Evaluation of long-term intravitreal anti-vascular endothelial growth factor injections on renal function in patients with and without diabetic kidney disease [J].BMC Nephrol,2019,20(1):478. |
|
|
|
2023, Vol. 40 
