|
|
Relationship between Mean Platelet Volume and Short-term Clinical Prognosis in Patients with Acute Cerebral Infarction |
QU Xing-han, JIA Jun, HUANG Liang |
Department of Neurology,Chenggu County Hospital,Hanzhong Shaanxi 723200 |
|
|
Abstract 【Objective】 To analyze the relationship between mean platelet volume (MPV) and clinical prognosis within 30 days of acute cerebral infarction (ACI). 【Methods】 A total of 50 patients with ACI who were diagnosed within 24 hours in our hospital were enrolled in the study. After conventional effective treatment,3 patients died in the hospital,and the remaining 47 patients were discharged after treatment. The mRS score was performed from 47 patients with 30 days after discharge. According to the mRS scores,patients were divided into the good prognosis group (mRS≤2 score,n=33) and the poor prognosis group (mRS>2 score,n=14). The level of MPV were measured at admission,and the relationship between MPV and clinical prognosis of 30 days after ACI was analyzed. The receiver operating characteristic curve (ROC) was used to evaluate the value of MPV as a predictor of clinical prognosis in patients with ACI and the logistic regression analysis was used to determine whether MPV was an independent risk factor for poor prognosis.【Results】 The circulating MPV level of the poor prognosis group was (13.44±1.73) fL immediately after admission,which was significantly higher than (11.17±2.00) fL in the good prognosis group,and the difference was statistically significant (P<0.05). MPV had a moderate diagnostic efficacy for poor prognosis of ACI patients and the area under the ROC curve (AUC) (95%CI) was 0.83 (0.72-0.95). Logistic regression analysis showed that MPV was an independent risk factor for poor prognosis within 30 days of ACI patients. 【Conclusion】 MPV is an independent risk factor for poor prognosis in ACI patients within 30 days,and it is a potential marker for evaluating poor prognosis in ACI patients.
|
Received: 10 May 2022
|
|
|
|
|
[1] 孟聪聪,于卫刚,王瑞涛. 平均血小板体积与心脑血管疾病[J].中华老年心脑血管病杂志,2012,14(2):218-220. [2] 刘茂春,郑晓梅,普娟. 急性脑梗死患者外周血平均血小板体积与颈动脉粥样硬化的相关性研究[J].医学研究杂志,2018,47(3):146-149. [3] 武喆,韩登峰,张小宁. 纤维蛋白原和血小板平均体积与急性脑梗死相关性研究[J].神经损伤与功能重建,2014,9(1):20-21. [4] 华医学会神经病学分会,中华医学会神经病学分会脑血管 病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257. [5] 丁帅,周霞,孙中武. 脑白质病变与急性脑梗死患者近期预后的关系[J].山东医药,2016,56(27):47-49. [6] VAN SWIETEN J C,KOUDSTAAL P J,VISSER M C,et al.Interobserver agreement for the assessment of handicap in stroke patients[J].Stroke,1988,19(5):604-607. [7] 何宝强,李晓梅.急性心肌梗死患者平均血小板体积变化的意义[J].心血管病学进展,2018,39(2):235-238. [8] 郭伟莉. 血小板平均体积对急性脑梗死患者近期预后的影响[J].临床荟萃,2001,16(18):850. [9] 江飞飞,林海燕,丁美萍. 急性脑梗死患者血小板超微结构及相关参数变化的研究[J].浙江医学,2016,38(2):126-127. [10] 欧阳存. 急性脑卒中血小板计数与血小板平均体积变化[J].中风与神经疾病杂志,2000,17(6):340-342. |
|
|
|