负压封闭引流术联合高压氧治疗四肢大面积软组织创伤患者的疗效及对IFN-γ、TNF-α水平的影响

doi:10.3969/j.issn.1671-7171.2023.03.022

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Abstract 【Objective】 To explore the effect of vacuum sealing drainage combined with hyperbaric oxygen on large area soft tissue trauma of extremities and its effect on tumor necrosis factor-α(TNF-α) and interferon- γ(IFN-γ). 【Methods】 From April 2019 to April 2022,100 patients with large area soft tissue trauma of extremities admitted to the Third Hospital of Shandong Province were randomly divided into the drainage group and the combined group,with 50 patients in each group. The drainage group was treated with negative pressure sealing drainage alone,while the combined group was treated with hyperbaric oxygen in addition to the negative pressure sealing drainage. After 2 weeks of treatment,the clinical efficacy,wound dressing change frequency,hospitalization time,pain degree and inflammatory indicators TNF-α and IFN-γ and the incidence of adverse reactions between the two groups were compared. 【Results】 The clinical effect of the combined group was better than that of the drainage group (P<0.05),and the hospitalization time was shorter than that of the drainage group (P<0.05). The overall analysis showed that there were statistically significant differences in VAS scores between the two groups before and after treatment (P<0.05). The VAS scores of the two groups after 48 hours and 2 weeks of treatment were lower than those before treatment (P<0.05). After 2 weeks of treatment,the VAS score of the combined group was lower than that of the drainage group (P<0.05). The serum TNF-α and IFN-γ levels in the two groups after treatment were lower than those before treatment. There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05).【Conclusion】 The application of negative pressure sealing drainage combined with hyperbaric oxygen in the treatment of large area soft tissue trauma of extremities is more conducive to promoting the recovery of patients' wounds,inhibiting the expression of inflammatory factors,relieving patients' postoperative pain,and improving the treatment effect and safety.

Key words： Extremities/IN Drainage/MT Hyperbaric Oxygenation/MT Tumor Necrosis Factor-alpha

Received: 14 October 2022

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	SUN Bao-ping
	WANG Guo-wei
	WANG Zheng-yu

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SUN Bao-ping,WANG Guo-wei,WANG Zheng-yu. Effect of Vacuum Sealing Drainage Combined with Hyperbaric Oxygen on Large Area Soft Tissue Trauma of Extremities and Effect on IFN-γ and TNF-α[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(3): 400-402.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2023.03.022 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2023/V40/I3/400

[1] 陈道才,谢娟,李红红,等. 可注射型富血小板纤维蛋白联合封闭式负压引流技术治疗慢性难愈性创面的应用研究[J].安徽医科大学学报,2021,56(10):1622-1626.
[2] KIM P J. Negative pressure wound therapy with instillation:International consensus guidelines update[J].Int Wound J,2020,17(1):174-186.
[3] 张舒曼. 负压封闭引流术为主综合治疗难愈性创面的研究[J].空军医学杂志,2022,38(2):158-160.
[4] 卢峰,栾文康,王金龙,等. 负压创面治疗联合高压氧治疗糖尿病足的临床疗效[J].中国美容整形外科杂志,2021,32(3):150-153.
[5] 藏琳琳,杨磊,赵春月,等. 封闭式负压引流术联合自体游离皮片植皮治疗四肢皮肤软组织感染创面的疗效观察[J].现代生物医学进展,2022,22(1):94-98.
[6] 阮传江,韩玉虎,石兴磊,等. 负压引流技术对下肢开放损伤创面修复的效果[J].现代科学仪器,2021,38(5):133-136.
[7] 杨列浩,秦海燕,潘凌峰,等. 封闭式负压引流联合高压氧治疗慢性难愈性创面的系统评价[J].中国美容整形外科杂志,2022,33(3):154-157.
[8] O'MALLEY P,MCDONNELL C. Negative pressure wound therapy-two novel approaches to healing dehisced vascular bypass wounds[J].J Wound Care,2021,30(6):449-453.
[9] 邱海军,潘力生. 负压封闭引流技术联合自体游离皮片移植对下肢静脉性溃疡病人创面愈合及生活质量评分的影响[J].临床外科杂志,2021,29(2):188-190.
[10] 张美娟,林贝,刘凯明. 改良式简易封闭负压引流技术联合全面护理在断肢再植患者术后创面修复中的应用[J].中国美容医学,2021,30(5):162-165.
[11] 黄顺勇,陈前芬,韦庆,等. 负压封闭引流技术联合康复新液外用治疗四肢损伤性创面的效果[J].广西医学,2020,42(13):1740-1742.
[12] POUZET L,LANCIEN U,HAMEL A,et al. Negative pressure wound therapy in children:a 25 cases series[J].Ann Chir Plast Esthet,2021,66(3):242-249.
[13] 郑军,佟向阳. 骨外露创面扩创术修复后负压封闭引流联合局部氧疗的疗效及预后分析[J].中国现代医学杂志,2021,31(4):86-91.
[14] 李文波,刁春鹏,吕兴波,等. 高压氧联合超声清创术对糖尿病足溃疡创面细菌清除及微循环的影响[J].中华航海医学与高气压医学杂志,2021,28(1):64-68.
[15] 杨芷,石小花,田甜,等. 高压氧联合成纤维细胞生长因子治疗皮肤创伤对患者创面愈合与血清指标的影响[J].中华航海医学与高气压医学杂志,2021,28(4):484-488.
[16] 李璐,尹燕锋,杨越,等. IFN-γ对乳腺癌溃疡创面组织中成纤维细胞的影响[J].中国美容医学,2021,30(3):99-101.
[17] 刘璇,吴磊. 血清IL-6、TNF-α、CRP及CD64对老年烧伤感染患者病情及创面愈合程度评估的意义[J].中国老年学杂志,2019,39(13):3204-3207.

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