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| Expression of miR-1181 in Nasopharyngeal Carcinoma and its Clinical Significance |
| LUO Zhen-feng, YANG Hang, LI Heng |
| Department of Head and Neck Surgery,Ankang Central Hospital Otolaryngology,Ankang Shaanxi 725000 |
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Abstract 【Objective】To investigate the expression and clinical significance of microRNA-1181 (miR-1181) in nasopharyngeal carcinoma (NPC). 【Methods】 A total of 71 NPC patients who received surgical treatment in the Ankang Central Hospital from October 2019 to May 2021 were randomly recruited. The relative expression of miR-1181 in NPC tissues and normal tissues adjacent to cancer was detected by real-time fluorescent quantitative PCR (RT-PCR),and the relative expression of miR-1181 in NPC tissues of patients with different degrees of differentiation,clinical stages,and distant metastasis was compared. All patients were followed up to analyze the correlation between miR-1181 and the prognosis of NPC. 【Results】Compared with normal tissues adjacent to cancer,miR-1181 was significantly down-regulated in NPC tissues; The relative expression of miR-1181 in clinical stage Ⅲ+Ⅳ NPC tissues was lower than that in stage Ⅰ+Ⅱ NPC tissues,the relative expression of miR-1181 in moderately and poorly differentiated NPC tissues was lower than that in highly differentiated NPC tissues,and the relative expression of miR-1181 in NPC tissues with distant metastasis was lower than that in non-metastatic NPC tissues,the difference was statistically significant (P<0.05). The relative expression of miR-1181 in patients with good prognosis was significantly higher than that in patients with poor prognosis (P<0.05); Logistic regression analysis showed that miR-1181<3.59 was associated with poor prognosis of NPC,and its odds ratio (OR)(95%CI) was 3.52 (1.65~5.28). 【Conclusion】 miR-1181 is low expression in NPC tissues,and high expression in NPC tissues with high differentiation,low clinical stage and distant metastasis,and miR-1181<3.59 is a risk factor for poor prognosis of NPC patients.
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Received: 06 May 2022
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[1] 代森林,李晓倩,吴杰,等.鼻咽癌CNE2干样细胞具有干细胞特性及较高水平的自噬表达[J].中国组织工程研究,2019,23(17):2703-2708.
[2] 李燕娴,李宇,郭戈杨,等.同时期化疗联合放疗治疗老年鼻咽癌患者的安全性和疗效分析[J].肿瘤药学,2020,10(2):196-201.
[3] 陈琦,陈旋,游览,等. 重组人血管内皮抑制素联合NP方案治疗复发和转移性鼻咽癌的临床疗效[J].医学临床研究,2021,38(12):1771-1773.
[4] 李卫,黄定贵,瞿申红,等. EB病毒抗体筛查对体检人群早期鼻咽癌的诊断价值[J].广西医学,2020,42(18):2404-2408.
[5] 章凯,王建洪,罗小邹. miRNA-7在鼻咽癌中的表达及临床意义[J].中国耳鼻咽喉头颈外科,2018,25(9):478-480.
[6] 孙瑜宁,张美丽,张恩东. miRNA调控EMT机制对鼻咽癌细胞侵袭及迁移的影响[J].实用癌症杂志,2019,34(3):381-384.
[7] 周苏娜,张明鑫,张琰君,等. miRNA-381表达及其与鼻咽癌放疗敏感性的关系[J].现代肿瘤医学,2017,25(19):3042-3046.
[8] 王杰,喻超,周显飞,等. miRNA-1181抑制人胰腺癌细胞的增殖[J].贵州医科大学学报,2016,41(12):1382-1386.
[9] 孙栋勋,黄栋栋,金巧智,等. miRNA-7介导Bax和Bcl-2表达对人鼻咽癌CNE-1细胞凋亡的影响[J].中国病理生理杂志,2016,32(5):933-937.
[10] 中国抗癌协会肿瘤标志专业委员会鼻咽癌标志物专家委员会. 鼻咽癌标志物临床应用专家共识[J].中国癌症防治杂志,2019,11(3):183-193.
[11] 肖洋洋,卿吉琳,李宝绚,等.鼻咽癌实验动物模型的研究进展[J].中国比较医学杂志,2018,28(12):108-112.
[12] 赵海军,宋建涛,田红,等. 18F-FDG PET-CT在鼻咽癌诊断及预后评估中的应用价值[J].中国CT和MRI杂志,2020,18(7):29-32.
[13] 牛善利,满敏,牛传贵. miRNA-135b对鼻咽癌细胞侵袭和转移的促进作用[J].中国现代医学杂志,2018,28(36):18-22.
[14] 刘春丽,张洁,郭霞,等. 鼻咽癌患者中的miR-10b表达及调控机制研究[J].广东医学,2020,41(3):243-246.
[15] 梅雪霜,胡洪义,田怀谷,等. 抑制 miR-210 的表达对鼻咽癌放射抵抗细胞敏感性的影响[J].中国老年学杂志,2019,39(7):1669-1672.
[16] SONG Z,YU Z,CHEN L,et al. MicroRNA-1181 supports the growth of hepatocellular carcinoma by repressing AXIN1 [J].Biomed Pharmacother,2019,119:109397.
[17] JIANG J,LI Z,YU C,et al. MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer [J].Cancer Lett,2015,356:962-970.
[18] 王杰,喻超,周显飞,等. miRNA-1181通过抑制STAT3影响人胰腺癌细胞的侵袭转移能力[J].贵州医科大学学报,2016,41(12):1387-1392.
[19] 姚梦纤,谢辰,庄志祥.血清中miR-1181表达水平与鼻咽癌预后的相关性分析[J].中国中西医结合耳鼻咽喉科杂志,2020,28(4):241-246. |
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2023, Vol. 40 
