|
|
|
| Study on Relationship of Peripheral Blood MIF with Severity of Sepsis for Predictive Value of ARDS |
| BIAN Mao-cheng, ZHONG Fei, WAN Jian |
| Department of Emergency and Critical Medicine,Pudong New Area People's Hospital,Shanghai 210299 |
|
|
|
|
Abstract 【Objective】To explore the relationship of peripheral blood macrophage migration inhibitory factor (MIF) with the severity of sepsis to predict complication of acute respiratory distress syndrome (ARDS). 【Methods】A total of 95 patients with sepsis admitted to the hospital were selected. The basic data of all patients and biochemical indicators before treatment were collected. Patients were followed up for 2 weeks after treatment. Peripheral blood MIF,acute physiology and chronic health score Ⅱ(APACHE Ⅱ),and sequential organ failure assessment (SOFA) scores of sepsis patients with different severity levels were analyzed. Factors affecting ARDS in patients with sepsis were analyzed. And the value of peripheral blood MIF in predicting ARDS in patients with sepsis was analyzed as well. 【Results】The scores of MIF,APACHE Ⅱ and SOFA in the septic shock group were higher than those in the sepsis group (P<0.05). Pearson correlation analysis showed that the level of MIF in patients with sepsis was positively correlated with APACHE Ⅱ score and SOFA score (P<0.05). Logistic multivariate regression analysis showed that APACHE Ⅱ score,MIF,and oxygenation index were independent factors that affected patients with sepsis complicated by ARDS (P<0.05). ROC curve analysis showed that the sensitivity,specificity,and area under AUC of peripheral blood MIF in predicting sepsis patients with ARDS were 71.43%,79.66%,and 0.778,respectively. 【Conclusion】The level of peripheral blood MIF in patients with sepsis is related to the severity of the disease and ARDS complication. MIF is effective in predicting ARDS in patients with sepsis.
|
|
Received: 16 June 2022
|
|
|
|
|
|
[1] SPINELLI E,MAURI T,BEITLER J R,et al. Respiratory drive in the acute respiratory distress syndrome:pathophysiology,monitoring,and therapeutic interventions[J].Int Care Med,2020,46(4):606-618.
[2] WILLIAMS G W,BERG N K,RESKALLAH A,et al. Acute respiratory distress syndrome[J].Anesthesiology,2021,134(2):270-282.
[3] QIN H,ZHAO A. Mesenchymal stem cell therapy for acute respiratory distress syndrome:from basic to clinics[J].Protein Cell,2020,11(10):707-722.
[4] BAYRAKTAR S. Umbilical cord levels of macrophage migration inhibitory factor in neonatal respiratory distress syndrome[J].Turk J Med Sci,2021,51(2):722-726.
[5] 中国中西医结合学会急救医学专业委员会,《中国中西医结合急救杂志》编辑委员会. 脓毒症中西医结合诊治专家共识[J].中华危重病急救医学,2013,25(4):194-197.
[6] PAN K,PANWAR A,ROY U,et al. A comparison of the intracerebral hemorrhage score and the acute physiology and chronic health evaluation Ⅱ score for 30-day mortality prediction in spontaneous intracerebral hemorrhage[J].J Stroke Cerebrovasc Dis,2017,26(11):2563-2569.
[7] AHTIALA M,SOPPI E,SAARI T I. Sequential organ failure assessment (SOFA) to predict pressure ulcer risk in intensive care patients:a retrospective cohort study[J].Ostomy Wound Manage,2018,64(10):32-38.
[8] 中华医学会重症医学分会. 急性肺损伤/急性呼吸窘迫综合征诊断和治疗指南(2006)[J].中国实用外科杂志,2007,28(1):19-28.
[9] 郭小芙,席与斌,陈刚. 血清HMGB1、ESM-1水平对脓毒症并发ARDS的预测价值[J].山东医药,2020,60(31):32-35.
[10] JALCE G,GUIGNABERT C. Multiple roles of macrophage migration inhibitory factor in pulmonary hypertension[J].Am J Physiol Lung Cell Mol Physiol,2020,318(1):L1-L9.
[11] REILLY J P,CALFEE C S,CHRISTIE J D. Acute respiratory distress syndrome phenotypes[J].Semin Respir Crit Care Med,2019,40(1):19-30.
[12] SALLES É L,KHODADADI H,JARAHI A,et al. Cannabidiol (CBD) modulation of apelin in acute respiratory distress syndrome[J].J Cell Mol Med,2020,24(21):12869-12872.
[13] BILSBORROW J B,DOHERTY E,TILSTAM P V,et al. Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus[J].Expert Opin Ther Targets,2019,23(9):733-744. |
|
|
|
2023, Vol. 40 
