Abstract 【Objective】To investigate the relationship between the middle cerebral artery (MCA) atherosclerotic plaque and its correlation with acute cerebral infarction (ACI). 【Methods】A total of 56 patients with symptomatic middle cerebral artery stenosis were collected and divided into acute cerebral infarction group(ACI group) and non-acute cerebral infarction(NACI group) according to diffusion weighted imaging (DWI). First,Univariate analysis was used to analyze the differences in the differences the lumen stenosis rate,plaque location,shape,length and enhancement degree between the two groups of patients. Binary logistic regression and receiver operating characteristic (ROC) curve were constructed to evaluate the efficacy of selected variables in predicting cerebral infarction. 【Results】The plaque length and the proportion of plaque enhancement in the ACI group were higher than those in the NACI group,the difference was statistically significant (P<0.05). Multivariate logistic regression analysis showed that plaque length and plaque enhancement were independent risk factors for ACI in patients with symptomatic MCA stenosis (P<0.05). The AUC of lumen stenosis rate,plaque length,plaque enhancement and their combination to predict the occurrence of ACI were 0.611,0.836,0.782 and 0.877,respectively. The predictive efficacy of plaque length and plaque enhancement degree on cerebral infarction was higher than lumen stenosis rate (P<0.05),and the combination of the three could significantly improve the predictive efficacy of cerebral infarction (P<0.05). 【Conclusion】The length and intensity of plaque are independent risk factors for ACI in patients with symptomatic MCA stenosis. Both of them are superior to lumen stenosis in predicting the occurrence of acute cerebral infarction. The combined detection of the three can improve the diagnostic efficacy of ACI.
NIU Wen,QIU Xiao-hui,LIU Yi-chao. Imaging Characteristics of the Middle Cerebral Artery Atherosclerotic Plaque and its Correlation with Acute Cerebral Infarction[J]. JOURNAL OF CLINICAL RESEARCH, 2023, 40(2): 161-164.
[1] WANG Y,ZHAO X,LIU L,et al. Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China:the Chinese Intracranial Atherosclerosis (CICAS) Study[J].Stroke,2014,45(3):663-669.
[2] FAKIH R,ROA J A,BATHLA G,et al. Detection and quantification of symptomatic atherosclerotic plaques with high-resolution imaging in cryptogenic stroke[J].Stroke,2020,51(12):3623-3631.
[3] 虞雁南,许玉园,李明利,等. 大脑中动脉粥样硬化的狭窄度与卒中机制:一项高分辨磁共振研究[J].中国卒中杂志,2016,11(8):619-625.
[4] SONG J W,WASSERMAN B A. Vessel wall MR imaging of intracranial atherosclerosis[J].Cardiovasc Diagn Ther,2020,10(4):982-993.
[5] KWEE R M,QIAO Y,LIU L,et al. Temporal course and implications of intracranial atherosclerotic plaque enhancement on high-resolution vessel wall MRI[J].Neuroradiology,2019,61(6):651-657.
[6] 殷亮,王晶,韩武师,等. 大脑中动脉斑块特征与缺血性脑卒中相关性的高分辨MRI研究[J].医学影像学杂志,2022,32(3):379-382.
[7] 宋明慧,岳云龙,郭劲松,等. MRI 3D SNAP序列对大脑中动脉斑块内出血的研究[J].中国医学影像学杂志,2021,29(2):131-135.
[8] ZHANG T,TANG R,LIU S,et al. Plaque characteristics of middle cerebral artery assessed using strategically acquired gradient echo (STAGE) and vessel wall MR contribute to misery downstream perfusion in patients with intracranial atherosclerosis[J].Eur Radiol,2021,31(1):65-75.
[9] EDJLALI M,QIAO Y,BOULOUIS G,et al. Vessel wall MR imaging for the detection of intracranial inflammatory vasculopathies[J].Cardiovasc Diagn Ther,2020,10(4):1108-1119.
[10] AMELI R,EKER O,SIGOVAN M,et al. Multifocal arterial wall contrast - enhancement in ischemic stroke:A mirror of systemic inflammatory response in acute stroke[J].Rev Neurol (Paris),2020,176(3):194-199.
[11] WU F,MA Q,SONG H,et al. Differential features of culprit intracranial atherosclerotic lesions:A whole-brain vessel wall imaging study in patients with acute ischemic stroke[J].J Am Heart Assoc,2018,7(15):1-11.
[12] LU Y,YE M F,ZHAO J J,et al. Gadolinium enhancement of atherosclerotic plaque in the intracranial artery[J].Neurol Res,2021,43(12):1040-1049.
[13] HARTEVELD A A,VAN DER KOLK A G,VAN DER WORP H B,et al. High-resolution intracranial vessel wall MRI in an elderly asymptomatic population:comparison of 3T and 7T[J].Eur Radiol,2017,27(4):1585-1595.
2023, Vol. 40 
