|
|
|
| Effect of Nalbuphine on Intraoperative Analgesia and Hemodynamics in Children Undergoing Daytime Surgery |
| LI Ling-qing, WU Lan-ping, CHEN Zheng, et al |
| Department of Anesthesiology and Surgery,Hunan Children's Hospital,Changsha Hunan 410007 |
|
|
|
|
Abstract 【Objective】To investigate the analgesic effect of nalbuphine during daytime operation in children and its influence on hemodynamics. 【Methods】The clinical data of 60 children who underwent unilateral hernia sac high ligation in our hospital from November 2020 to February 2021 were analyzed retrospectively. According to the different anesthetics used, they were divided into Nabufen group and Sufentanil group, with 30 cases in each group. The mean arterial pressure (MAP), heart rate (HR) and respiratory rate (RR) of the two groups were observed and recorded at the time of LMA insertion (T1), skin incision (T2), hernia sac ligation (T3), the end of surgery (T4), and 5 minutes after extubation (T5); The effects of sedation and analgesia were evaluated with FLACC pain score and Ramsay sedation score, and the adverse reactions of the two groups were recorded. 【Results】MAP and HR at T3 were significantly different from those at T1 in the same group (P<0.05); MAP and HR at T3 and T4 in sufentanil group were significantly different from those at T1 in the same group (P<0.05), and MAP and HR at the above time points were significantly different from those in nalbuphine group (P<0.05). There was no significant difference in the proportion of different FLACC scores between the two groups (P>0.05). The proportion of different Ramsay sedation scores in the two groups was statistically significant (P=0.03). The total incidence of adverse reactions in the sufentanil group was higher than that in the control group, with a statistically significant difference (P<0.05). 【Conclusion】Nabuphine can provide effective analgesic effect, more stable hemodynamics and better safety during daytime operation in children.
|
|
Received: 24 October 2022
|
|
|
|
|
|
[1] 李延辉.腹腔镜下疝囊高位结扎日间手术治疗小儿腹股沟疝的疗效[J].实用临床医学,2013,14(4):51-52.
[2] 汪琼,佐满珍,郑文斐.丙泊酚联合瑞芬太尼静脉泵注对无痛人工流产早孕妇女认知功能影响的临床研究[J].中国全科医学,2012,15(11):1231-1233.
[3] 闫诺,杨程,陈宁.地佐辛联合舒芬太尼用于术后自控静脉镇痛效果观察[J].海南医学院学报,2011,17(3):403-405.
[4] SCHULTZ-MACHATA A M,BECKE K,WEISS M. Nalbuphine in pediatric anesthesia[J].Der Anaesthesist,2014,63(2):135-143.
[5] BANG S,YOO S,OH U,et al. Endogenous lipid-derived ligands for sensory TRP ion channels and their pain modulation[J].Arch Pharm Res,2010,33(10):1509-1520.
[6] HOBSON A,WIFFEN P J,CONLON J A. As required versus fixed schedule analgesic administration for postoperative pain in children[J].Cochrane Database Syst Rev,2015,2015(2):CD011404.
[7] ZENG Z,LU J,SHU C,et al. A comparision of nalbuphine with morphine for analgesic effects and safety :meta-analysis of randomized controlled trials[J].Sci Rep,2015,5:10927.
[8] 陈政,付楚杰,彭拓超,等.盐酸纳布啡用于小儿尺桡骨骨折闭合复位克氏针内固定术后镇痛的临床观察[J].临床小儿外科杂志,2019,18(6):503-507.
[9] DONG Y,LIANG Z,XU Z,et al. Effects of dezocine,morphine and nalbuphine on electropain threshold,temperature pain threshold and cardiac function in rats with myocardial ischemia[J].Ann Palliat Med,2020,9(4):1556-1563.
[10] LAKE C L,DUCKWORTH E N,DIFAZIO C A,et al. Cardiovascular effects of nalbuphine in patients with coronary or valvular heart disease[J].Anesthesiology,1982,57(6):498-503.
[11] ZSIGMOND E K,WINNIE A P,RAZA S M,et al. Nalbuphine as an analgesic component in balanced anesthesia for cardiac surgery[J].Anesth Analg,1987,66(11):1155-1164.
[12] CHAWDA P M,PAREEK M K,MEHTA K D. Effect of nalbuphine on haemodynamic response to orotracheal intubation[J].J Anaesthesiol Clin Pharmacol,2010,26(4):458-460. |
|
|
|
2022, Vol. 39 
