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| Level Changes and Clinical Significance of Serum Five Tumor Markers and Procalcitonin before and after Chemotherapy in Lung Adenocarcinoma |
| XU Li-hong, WANG Yu, YUE Hong |
| Department of Laboratory,Shaanxi Honorary Military Rehabilitation Hospital,Huayin Shaanxi 714200 |
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Abstract 【Objective】To explore the changes and clinical significance of serum five tumor markers and procalcitonin (PCT) levels before and after chemotherapy for lung adenocarcinoma.【Methods】A total of 124 patients with lung adenocarcinoma two were treated with paclitaxel (or docetaxel) chemotherapy on the basis of routine treatment.Five tumor cell markers in serum [carcinoembryonic antigen (CEA),alpha fetoprotein (AFP),glycoprotein antigen 19-9 (CA19-9),glycoprotein antigen 125 (CA-125),glycoprotein antigen 15-3 (CA15-3)] and PCT were detected. Changes of the above indicators before and after chemotherapy were compared between the chemotherapy effective group and the ineffective group,the two-year survival group and the death group.【Results】The overall analysis of patients with lung adenocarcinoma showed that the levels of serum CEA,CA-125 and PCT after treatment were lower than those before treatment (P<0.05).Among 124 patients with lung adenocarcinoma,74 patients (59.68%) were effective in treatment,and 50 patients (40.32%) were ineffective in chemotherapy.The serum CEA and CA-125 levels in the two groups after treatment were lower than those before treatment,and the serum PCT levels in the chemotherapy effective group after treatment were lower than those before treatment (P<0.05).After treatment,serum CEA,CA-125 and PCT levels in the effective group were lower than those in the ineffective group (P<0.05).Among 124 patients with lung adenocarcinoma,28 patients (22.58%) had a survival period of ≥ 2 years,and 96 patients (77.42%) died within 2 years.The levels of serum CEA,CA-125 and PCT in the two groups after treatment were lower than those before treatment,and those in the survival group were lower than in the death group (P<0.05).The rates of serum CEA,CA-125 and PCT level decrease in the survival group after chemotherapy were higher than those in the death group (P<0.05).【Conclusion】The changes of serum CEA,CA-125 and PCT levels are closely related to the curative effect and prognosis of patients with lung adenocarcinoma,which can be used to assist in evaluating the disease progression and prognosis of patients with lung adenocarcinoma.
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Received: 15 March 2022
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2022, Vol. 39 
