|
|
|
| Analysis of Clinical Effect of Venlafaxine Combined with Namefene in the Treatment of Alcoholic Mental and Behavioral Disorders |
| XU Juan, LI Xiao-xue |
| Ankang Center for Disease Control and Preverntion,Ankang Shaanxi 725000 |
|
|
|
|
Abstract 【Objective】To investigate the clinical effect of venlafaxine combined with Namefene in the treatment of alcoholic mental and behavioral disorders.【Methods】A total of 72 patients with alcoholic mental and behavioral disorders admitted to Ankang Central Hospital from May 2019 to March 2020 were randomly divided into observation group and control group with 36 patients in each group. The control group was treated with routine therapy and Namefene, while the observation group was treated with venlafaxine on the basis of the control group. The therapeutic effect, adverse reaction rate, PANSS score, levels of neurocytokines [brain derived neurotrophic factor(BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3)], and the scores of Loewenstein Occupational Therapy Cognitive Assessment Scale (LOTCA) and Montreal Cognitive Assessment Scale (MoCA) before and after treatment were compared between the two groups. 【Results】 After 28 days of treatment, the total effective rate in the observation group was 94.44% (34/36), higher than that in the control group [77.78% (28/36)], with a statistically significant difference(χ2=4.18,P=0.04);The positive symptom score, negative symptom score, general psychopathology score and total score of the two groups were lower than those before treatment, and the observation group was lower than the control group, with a statistically significant difference (P<0.05); The levels of serum BDNF, NGF and NT-3 in the two groups were higher than those before treatment, and those in the observation group were higher than those in the control group, with a statistically significant difference (P<0.05); The scores of LOTCA and MoCA in the two groups were higher than those before treatment, and those in the observation group were higher than those in the control group, with a statistically significant difference (P<0.05). There was no significant difference between the two groups in the incidence of nausea, vomiting, dizziness, lethargy, dry mouth, diarrhea and skin itching (P>0.05). 【Conclusion】 Venlafaxine combined with Namefene is helpful to regulate the level of neurocytokines in patients with alcoholic mental and behavioral disorders, improve clinical treatment effect, improve mental symptoms, reduce cognitive dysfunction, and has good safety.
|
|
Received: 20 August 2021
|
|
|
|
|
|
[1] 赵林,方慧,孙波,等.酒精所致的精神和行为障碍患者血浆非酶抗氧化物浓度的变化[J].中国药物滥用防治杂志,2021,27(1):44-47.
[2] SOYKA M,FRIEDE M,SCHNITKER J.Comparing nalmefene and naltrexone in alcohol dependence:are there any differences? Results from an indirect meta-analysis[J].Pharmacopsychiatry,2016,49(2):66-75.
[3] 张光勇,王荣科,周豪.低频重复经颅磁刺激对酒依赖患者急性戒断后焦虑、抑郁和复饮的效果[J].四川精神卫生,2019,32(4):342-345.
[4] 孙军伟,李作佳,邹旭明,等.正念认知疗法联合文拉法辛对抑郁症患者心理状态和生活质量的影响[J].国际精神病学杂志,2020,47(3):482-484.
[5] 中华医学会精神病学分会.中国精神障碍分类与诊断标准第三版(精神障碍分类)[J].中华精神科杂志,2001,34(3):184-188.
[6] 陈意飞,马红,郭明,等.纳美芬联合纳洛酮治疗急性重度酒精中毒的疗效观察[J].实用临床医药杂志,2020,24(21):15-18.
[7] 蒋甜鑫,刘晓东,刘李.文拉法辛治疗抑郁症的机制和临床应用研究进展[J].现代药物与临床,2021,36(1):197-203.
[8] 王俊,杜云红,刘建萍.文拉法辛联合舍曲林治疗抑郁症临床疗效及对患者认知功能 hs-CRP的影响[J].临床心身疾病杂志,2019,25(4):43-45.
[9] 杨雪,刘忠纯.tDCS治疗物质依赖的效果及对患者睡眠质量的影响[J].解放军预防医学杂志,2019,37(2):63-65.
[10] 袁利艳,杨颜滋,李江琳.氟西汀与阿米替林对酒精依赖戒断后情绪障碍的疗效比较[J].国际精神病学杂志,2020,47(3):507-509.
[11] ALMOMANI F,AVIITZHAK T,DEMETER N,et al.Construct validity and internal consistency reliability of the Loewenstein occupational therapy cognitive assessment (LOTCA)[J].BMC Psychiatry,2018,18(1):184.
[12] 中国医师协会神经内科分会脑与脊髓损害专业委员会.慢性酒精中毒性脑病诊治中国专家共识[J].中华神经医学杂志,2018,17(1):2-9.
[13] 董小林,马鹏程,战丽萍,等.慢性酒精中毒性脑病认知功能障碍的相关性分析[J].精神医学杂志,2020,33(2):108-111. |
|
|
|
2022, Vol. 39 
