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| Correlation of CER,GP73 and Liver Hardness with Hepatic Fibrosis Stage in Chronic Hepatitis B Patients with Slightly Elevated ATL |
| LI Dan-jie, WEI Xiao-qiang |
| Department of Blood Transfusion,Navy 905 Hospital,Shanghai 200052 |
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Abstract 【Objective】To investigate the correlation of serum golgi protein 73 (GP73),ceruloplasmin (CER) and liver stiffness/hardness (LSM) with liver fibrosis stage in chronic hepatitis B (CHB) patients with slightly elevated alanine aminotransferase (ATL).【Methods】A total of 122 CHB patients were selected as the observation group.In addition,100 healthy volunteers were selected as the control group.CER,GP73 and LSM levels were compared between the two groups.And levels of CER,GP73 and LSM were compared in CHB patients with different stages of liver fibrosis as well.The diagnostic value of CER,GP73 and LSM in CHB diagnosis and their relationship with liver fibrosis stage were determined by ROC and correlation analysis.【Results】The CER level in the observation group was significantly lower than that in the control group (P<0.05).The levels of GP73 and LSM in the observation group were significantly higher than those in the control group (P<0.05).ROC analysis confirmed that the areas under the curve of CER,GP73 and LSM for CHB diagnosis were 0.718,0.859 and 0.905,respectively (P<0.05).The value of CER in CHB patients with different stages of liver fibrosis was S1>S2>S3>S4,and the differences were statistically significant (P<0.05).While the levels of GP73 and LSM in CHB patients with different stages of liver fibrosis were S1<S2<S3<S4,and the differences were statistically significant (P<0.05).Correlation analysis confirmed that CER was negatively correlated with liver fiber staging in CHB patients,while GP73 and LSM were positively correlated with liver fiber staging in CHB patients (all P<0.05).【Conclusion】CER of CHB patients with ALT≤2× upper limit of normal value (ULN) decreased significantly,while GP73 and LSM increased significantly.Thus these changes can be used for disease diagnosis.They are closely related to the severity of liver fibrosis,which is worthy of clinical attention.
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Received: 10 April 2022
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2022, Vol. 39 
