3D及2D胸腔镜模式下肺癌根治术对肺癌患者围术期免疫功能的影响

doi:10.3969/j.issn.1671-7171.2022.08.018

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Abstract 【Objective】 To to explore the effect of 3D and 2D thoracoscopic radical resection on perioperative immune function of patients with lung cancer. 【Methods】 The clinical data of 59 patients with lung cancer who underwent thoracoscopic radical resection of lung cancer in Suqian Hospital of Nanjing Drum Tower Hospital Group and the Nanjing Gulou Hospital from March 2019 to March 2022 were retrospectively analyzed. According to the different surgical methods, they were divided into observation group (n=30) and control group (n=29). Patients in the observation group underwent radical lung cancer surgery with 3D video-assisted thoracoscopy system, while patients in the control group underwent radical lung cancer surgery with 2D video-assisted thoracoscopy system. The perioperative operation time, intraoperative bleeding volume, number of lymph node dissections, retention time of drainage tube and hospitalization time were compared between the two groups. The levels of carcinoembryonic antigen (CEA), carbohydrate antigen 50 (CA50), cytokeratin 19 fragment antigen 21-1(CYFRA21-1) and T lymphocyte subsets CD4⁺, CD8⁺, CD4⁺/CD8⁺ before and after operation were compared between the two groups. The postoperative complications of the two groups were compared. 【Results】 The operation time, intraoperative bleeding volume, retention time of drainage tube and hospitalization time of the observation group were shorter than those of the control group, and the number of lymph node dissection was greater than that of the control group (P<0.05). There was no significant difference in CEA, CA50 and CYFRA21-1 between the two groups before and after operation (P>0.05); The levels of CEA, CA50 and CYFRA21-1 in both groups were significantly lower than those before operation (P<0.05). CD4⁺, CD8⁺, CD4⁺/CD8⁺ in both groups were significantly better than that before operation, and the observation group was significantly better than the control group (P<0.05). The total incidence of postoperative complications in the observation group was 13.33% (4/30), which was lower than that in the control group [20.69%(6/29)], but the difference was not statistically significant (P>0.05). 【Conclusion】Radical resection of lung cancer under 3D and 2D thoracoscopy has no significant effect on tumor marker level and complication rate of patients, but 3D thoracoscopy can shorten the operation time, drainage tube retention time, hospital stay, reduce intraoperative bleeding, and have little impact on the immune function of patients.

Key words： Lung Neoplasms/SU Thoracoscopy Perioperative Period Immunoassay

Received: 26 May 2022

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R734.2

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	LI Wei
	ZHOU Yong
	YOU Jin-zhi
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LI Wei,ZHOU Yong,YOU Jin-zhi, et al. Effect of 3D and 2D Thoracoscopic Radical Resection of Lung Cancer on Perioperative Immune Function of Patients with Lung Cancer[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(8): 1186-1189.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.08.018 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I8/1186

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