|
|
|
| Effects of Loading dose of Tegranolol before PCI on Coronary Blood Flow, Myocardial Zymogram and Hcy, FGF23, Klotho Protein in Patients with Acute Myocardial Infarction |
| CAI Hai-jun, ZHANG Pei |
| Ankang Hospital of Traditional Chinese Medicine,Ankang Shaanxi 725000 |
|
|
|
|
Abstract 【Objective】 To investigate the effects of loading dose tegrilol before early percutaneous coronary intervention (PCI) on coronary blood flow, myocardial zymogram, homocysteine (Hcy), fibroblast growth factor 23 (FGF23) and Klotho protein in patients with acute myocardial infarction (AMI). 【Methods】The clinical data of 180 AMI patients treated with PCI in our hospital from January 2017 to March 2019 were retrospectively analyzed. They were divided into control group (n=89) and observation group (n=91) according to different treatment methods. The myocardial blood perfusion immediately after operation, the peak time of five postoperative myocardial enzymes, the levels of Hcy, FGF23, Klotho protein at admission and 12 weeks after operation, cardiovascular events and adverse events were compared between the two groups. 【Results】The corrected TIMI blood flow frame number (cTFC) and the incidence of no reflow or slow blood flow after operation in the observation group were significantly lower than those in the control group (P<0.05);The peak time of Creatine kinase isoenzyme (CK-MB), creatine kinase phosphate (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), α-Hydroxybutyrate dehydrogenase(α-HBD) was significantly earlier than that of the control group (P<0.05). The levels of serum Hcy and FGF23 in the observation group were lower than those in the control group (P<0.05), and the level of Klotho protein was higher than that in the control group (P<0.05). There was no significant difference in the incidence of adverse events between the two groups during treatment (P>0.05). After 12 weeks of follow-up, the incidence of cardiovascular events in the observation group was significantly lower than that in the control group (P<0.05). 【Conclusion】The loading dose of tegranolol before PCI can effectively improve the coronary blood flow in patients with AMI, better alleviate the injury of myocardial cells, and reduce the incidence of cardiovascular events.
|
|
Received: 17 December 2021
|
|
|
|
|
|
[1] 王志清,罗助荣. 吲哚布芬在急性前壁心肌梗死并发左心室附壁血栓治疗中的应用1例报告[J].中国实用内科杂志,2019,12(7):23-26.
[2] 韩雅玲. 应用血管腔内影像学指导和优化经皮冠状动脉介入治疗[J].中华心血管病杂志,2019,11(1):3-4.
[3] 张立敏,王伟群,张明亮,等. 替格瑞洛及氯吡格雷对经皮冠状动脉介入治疗急性非ST段抬高型心肌梗死患者炎性因子的影响[J].中国老年学杂志,2018,38(9):2066-2067.
[4] 韩雅玲. 中国经皮冠状动脉介入治疗指南(2016)解读[J].中国循环杂志,2017,12(7):28-31.
[5] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会. 急性ST段抬高型心肌梗死诊断和治疗指南(2019)[J].中华心血管病杂志,2019,47(10):766-783.
[6] 董艳丽,董淑娟. 替格瑞洛片联合阿司匹林片用于经皮冠状动脉介入术的急性 ST 段抬高型心肌梗死患者的临床研究[J].中国临床药理学杂志,2019,21(7):4-7.
[7] 都虹,杨蓉,鲁雅楠,等. 替格瑞洛对不稳定型心绞痛患者经皮冠状动脉介入术围手术期血小板反应性及短期预后的影响[J].中国动脉硬化杂志,2019,27(11):965-968.
[8] HIATT W R,FOWKES F G,HEIZER G. Ticagrelor versus clopidogrel in symptomatic peripheral artery disease[J].N Engl J Med,2017,16(5):32-40.
[9] VENETSANOS D,LINDAHL T L,LAWESSON S S. Pretreatment with ticagrelor may offset additional inhibition of platelet and coagulation activation with bivalirudin compared to heparin during primary percutaneous coronary intervention[J].Thromb Res,2018,171:38-44.
[10] 周遊,马长胜. 血清cTnI、CK-MB及超声心动图检测对老年急性心肌梗死患者诊断的临床意义[J].中国老年学杂志,2019,34(3):531-533.
[11] 白娟,闫卫军. 负荷剂量替格瑞洛对急性心肌梗死患者介入治疗后冠脉血流,炎症反应及心肌酶谱的影响[J].临床和实验医学杂志,2018,17(7):757-760.
[12] 孙增玉,张秋梅,张伟,等. 补肾活血复方干预klotho蛋白对大鼠慢性心力衰竭心室重构的影响[J].中华中医药学刊,2019,19(9):2074-2076. |
|
|
|
2022, Vol. 39 
