全程新辅助治疗局部进展期中低位直肠癌的疗效及对恶性生物学标志基因表达的影响

doi:10.3969/j.issn.1671-7171.2022.06.027

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Abstract 【Objective】To analyze the effect of whole course neoadjuvant therapy on the curative effect of locally advanced middle and low rectal cancer and the expression of malignant biological marker genes in the lesions. 【Methods】A total of 74 patients with locally advanced middle and low rectal cancer who were admitted to our hospital were selected as the research subjects. They were randomly divided into the control group and the observation group,with 37 cases in each group. The control group was given neoadjuvant therapy before surgery,while the observation group was given whole course neoadjuvant therapy. The recent anti-tumor efficacy and lesion resection were compared between the two groups. The expression of biological marker genes in the lesions,drug safety and the prognosis of the two groups were counted as well. 【Results】The objective remission rate of the observation group was higher than that of the control group (P<0.05). The R0 resection rate in the observation group was higher than that in the control group (P<0.05). The relative expression levels of matrix metalloproteinase-11 (MMP-11) and Slug in the surgically removed lesions of the two groups were lower than before treatment (P<0.05). The relative expression levels of MMP-11 and Slug in the observation group were lower than those in the control group (P<0.05). The relative expressions of microtubule-related tumor suppressor genes 1 (MTUS1),matrix metalloproteinase 1 (TIMP1),Runx3,and p53 in surgically removed lesions were higher than before treatment in the two groups (P<0.05); And their relative expression levels in the observation group were higher than those in the control group (P<0.05). There was no significant difference in the incidence of hand-foot syndrome,nausea and vomiting,diarrhea,and peripheral neuropathy between the two groups (P>0.05). The three-year survival rates of the observation group was higher than that of the control group.The overall survival rate curves of the two groups were compared,and the difference between the two groups was statistically significant (P<0.05). 【Conclusion】The whole course neoadjuvant therapy can improve the short-term curative effect and surgical R0 resection rate in patients with locally advanced middle and low rectal cancer,inhibit cancer cell invasion,and improve the prognosis.

Key words： Chemotherapy, Adjuvant Rectal Neoplasms/GE Rectal Neoplasms/DT Genes

Received: 18 January 2022

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R735.35

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	DONG Fei-tian
	ZHANG Bo

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DONG Fei-tian,ZHANG Bo. Effect of Whole Course Neoadjuvant Therapy on Efficacy of Locally Advanced Middle and Low Rectal Cancer and Expression of Malignant Biological Marker Genes in the Lesion[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(6): 901-904.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.06.027 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I6/901

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