尿中性粒细胞明胶酶相关脂质运载蛋白与高血压患者早期肾损伤的相关性研究

doi:10.3969/j.issn.1671-7171.2022.06.018

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Abstract 【Objective】To investigate the relationship between urinary neutrophil gelatinase-associated lipocalin (NGAL) and early renal impairment in patients with hypertension. 【Methods】A total of 125 patients with hypertension who were treated in our hospital were recruited in the study. According to the 24-hour urine microalbumin excretion rate,a large number of proteinuria group (A group),micro-proteinuria group (B group) and normal proteinuria in the group (C group) were grouped. Healthy volunteers were selected as the control group. The serum creatinine (SCr),urea nitrogen (BUN),urinary NGAL and glomerular filtration rate (eGFR) were compared among those groups. The correlation of urinary NGAL to SCr,BUN and eGFR was analyzed. The ROC curve was used to analyze the value of urinary NGAL in the diagnosis of early renal damage in patients with hypertension. 【Results】Compared with the control group,the SCr,BUN,and urinary NGAL levels in the hypertension group significantly increased,while the eGFR levels significantly decreased (P<0.05).The SCr,BUN and urinary NGAL levels in the A group and B group were higher than those in the C group,while the levels of eGFR in both A and B groups were lower than that in the C group (P<0.05). The levels of BUN and urinary NGAL in the A group were higher than those in the B group (P<0.05). There was no significant difference in the levels of SCr and eGFR between the A group and B group (P>0.05).The SCr,BUN,and urinary NGAL levels in the death group were higher than those in the survival group,and the eGFR was lower than the survival group (P<0.05).Pearson correlation analysis showed that urinary NGAL level was positively correlated with SCr and BUN,and negatively correlated with eGFR ( P<0.05).The AUC of the ROC curve for urinary NGAL diagnosis of impaired renal function in early stage of hypertension was 0.884. When the cut-off point was 78.9 ng/mL,the sensitivity and specificity were 87.2% and 84.9%,respectively. 【Conclusion】The level of urinary NGAL is significantly elevated in patients with hypertension,and its level is positively correlated with the degree of early renal injury. It can be used as a reliable indicator for the diagnosis of early renal injury in hypertension.

Key words： Hypertension Renal Insufficiency Apolipoproteins Neutrophils

Received: 15 February 2021

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R544.1

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.06.018 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I6/866

[1] 朱运涛,张艳红.高血压性肾损害患者血清HCY、尿液β2-MG水平变化及意义[J].山东医药,2014,54(34):82-83.
[2] 郁迪,刘向祎.血浆和尿中性粒细胞明胶酶相关脂质运载蛋白在高血压肾损伤诊断中的应用[J].检验医学与临床,2017,14(11):1542-1544.
[3] 朱建锋,卢勤红.尿KIM-1、NGAL在心脏瓣膜置换术后急性肾损伤中的早期诊断意义[J].中国医师杂志,2015,17(6):942-944.
[4] 钟方明,高艳香,郑金刚.高血压肾损害发病机制的研究进展[J].中日友好医院学报,2015,29(6):364-366.
[5] 李云婷,吴琴玲,潘静.血清胱抑素C检测对糖尿病肾病患者早期诊断的临床研究[J].河北医药,2012,34(5):661-662.
[6] 陈薪薪,陈朝生,陈宇,等.血尿NGAL与IgA肾病临床与病理的相关性研究[J].中国中西医结合肾病杂志,2013,14(3):223-226.
[7] 张新明,卢玲玲,涂斐佩,等.高血压肾病早期血尿NGAL水平的变化及临床意义[J].中国免疫学杂志,2014,30(12):1672-1675.
[8] 张清平,邹长进,张敏.高血压肾病患者血清NGAL与Cys-c水平探讨[J].中国卫生检验杂志,2013,23(9):2203-2204.
[9] 张雅丽,崔丽艳,张捷. 中性粒细胞明胶酶相关脂质运载蛋白在急性肾损伤中的保护作用[J].检验医学,2015,30(1):80-84.
[10] MISHRA J,MORI K,MA Q,et al. Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin[J].J Am Soc Nephrol,2004,15(12):3073-3082.
[11] 牛栋,侯菲,周晶.尿中性粒细胞明胶酶相关脂质运载蛋白对高血压早期肾损害的预测价值[J].武警医学,2015,26(10):1021-1026.
[12] 吴家玉,熊冠泽,丁福全,等.血清胱抑素C和尿NGAL联合检测在急性肾损伤病情评估及预后中的价值[J].中山大学学报(医学科学版),2014,35(1):152-156.
[13] 奚希相,李文放,马金苗,等.尿NGAL联合MEDS评分评估脓毒症合并急性肾损伤患者病情及预后[J].第二军医大学学报,2017,38(2):244-248.