医学临床研究
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JOURNAL OF CLINICAL RESEARCH  2022, Vol. 39 Issue (5): 641-643    DOI: 10.3969/j.issn.1671-7171.2022.05.001
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Efficacy and Safety of Dual Bronchodilators (LABA/LAMA) for Treating Symptomatic COPD
YI Rong, XU Yu-zhu, FENG Ling, et al
Department of Pulmonary and Critical Care Medicine, Zhuzhou Central Hospital, Zhuzhou Hunan 412000
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Abstract  【Objective】 This study aimed to access the efficacy and safety of the medication use of long-acting β2-agonist combined with long-acting muscarinic antagonist (LABA/LAMA) for symptomatic COPD patients in the real world. 【Methods】 Patients were enrolled in the study cohort if they were diagnosed as COPD with CAT≥10 scores and new to LAMA/LABA treatment from the Second Xiangya Hospital of Central South University and Zhuzhou Central Hospital during December 2018 and January 2021.Patients enrolled in the study treated with LABA/LAMA 3 for months. According to whether other maintenance medication was used before enrollment, they were divided into 4 groups: the initial group, prior LAMA group,prior ICS/LABA group,prior ICS/LABA plus LAMA group. The effectiveness outcome was the change of CAT scores, the occurrence of moderate to severe acute exacerbations and clinical control during follow-up. Safety outcome was the appearance of adverse effects. 【Results】 Overall study population and patients from the initial group, prior LAMA group, prior ICS/LABA group ameliorated significantly in CAT scores (P<0.05), After 3 months, LABA/LAMA significantly reduced the rate of moderate or severe exacerbations(P<0.05). Study showed a significant improvement in clinical control (P<0.05). The overall incidence of adverse events is low. 【Conclusion】 Patients with COPD symptoms benefit from LABA/LAMA by improving their clinical symptoms, reducing the rate of moderate or severe exacerbations and improving clinical control rates. LABA/LAMA is safe and well tolerated.
Key wordsPulmonary Disease, Chronic Obstructive/DT      Bronchodilator Agents/AD     
Received: 11 June 2021     
PACS:  R563  
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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.05.001     OR     http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I5/641
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