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| Relationship of Proliferative Diabetic Retinopathy with Serum Magnesium and Glycosylated Albumin in Patients with Type 2 Diabetes Mellitus |
| ZHAO Hui, SHAO Xiao-han |
| Department of Neurology, Shandong Provincial Third Hospital, Jinan, Shandong 250031 |
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Abstract 【Objective】To investigate the relationship of proliferative diabetic retinopathy (PDR) with serum magnesium and glycosylated albumin in patients with type 2 diabetes mellitus (T2DM). 【Methods】A total of 90 patients with T2DM in our hospital from October 2017 to December 2018 were selected and divided into the proliferative diabetic retinopathy (PDR) group (n=42 cases) and non-proliferative diabetic retinopathy (NPDR) group (n=48 cases) according to the occurrence of PDR or not. The level of serum glycosylated albumin was detected by immunoturbidimetry and the level of serum magnesium was measured by enzyme-linked immunosorbent assay. The ROC curve was used to analyze the diagnostic efficacy of serum magnesium and glycosylated albumin in patients with T2DM complicated with PDR. In addition, logistic regression analysis was used to analyze the risk factors of PDR in patients with T2DM. 【Results】Compared with the NPDR group, the serum magnesium level in the group with PDR was lower (P<0.05), and the glycosylated albumin level was higher (P<0.05). The ROC curve showed that the area under curve (AUC) of serum magnesium and glycosylated albumin in the diagnosis of PDR in patients with T2DM were 0.699 and 0.768, their cut-off values were 0.79 mmol/L and 16.35%, respectively. The AUC of combined diagnosis of magnesium and glycosylated albumin was 0.857, which was significantly higher than that of serum magnesium and glycosylated albumin alone (P<0.05), the sensitivity and specificity were 71.4% and 87.5%, respectively. Serum magnesium, glycosylated albumin, triglyceride (TG), course of disease were the risk factors of PDR in patients with diabetes mellitus (P<0.05). 【Conclusion】The serum magnesium of patients with T2DM with PDR is significantly reduced, while glycosylated albumin is abnormally elevated, and both are risk factors for T2DM with PDR, which can be used as potential indicators for later disease diagnosis.
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Received: 06 December 2021
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(2): 284-286. |
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2022, Vol. 39 
