PCR检测Ⅰ期HER-2阳性乳腺癌患者腋窝淋巴结HER-2表达的意义

doi:10.3969/j.issn.1671-7171.2022.01.012

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Abstract 【Objective】Polymerase chain reaction (PCR) can improve the detection rate of micrometastasis. To detect HER-2 expression by PCR in axillary lymph nodes of stage Ⅰ HER-2-postive breast cancer and study its clinical significance. 【Methods】The clinical and pathological data of 128 cases of stage Ⅰ breast cancer with HER-2-postive expression were collected. HER-2 gene expression levels in axillary lymph nodes were detected by PCR. The clinicopathological characteristics, treatment and prognosis were retrospectively analyzed by using the statistical methods such as Kaplan-Meier. 【Results】The pathological type of 128 cases was infiltrative non-specific carcinoma with HER-2 positive expression and negative expression of ER and PR. During follow-up, 3 patients had local recurrence, 13 had distant metastases, and 10 patients had distant metastases who died during follow-up. DFS (disease-free survival) rate was 89.1% (114/128). PCR detection of HER-2 showed that 42 cases were positive expression and 86 cases were negative expression in axillary lymph nodes. The clinicopathological characteristics were not statistically different between the two groups (P>0.05). DFS rate was 78.6% (33/42) in HER-2 positive expression group and 94.2% (81/86) in HER-2 negative expression group, respectively; The difference of DFS rate was statistically significant (P<0.05). In HER-2 positive expression group, 27 patients received trastuzumab treatment and the DFS rate was 92.6% (25/27), while the DFS of 15 patients without receiving trastuzumab was 53.3% (8/15). The difference in DFS between the two groups was statistically significant (P<0.05). In HER-2 negative expression groups, DFS rate was 96.6% (56/58) in 58 cases who received trastuzumab and 89.3% (25/28) in 28 cases without receiving trastuzumab. The DFS rate of two groups had no significant difference (P>0.05). 【Conclusion】Overexpression of HER-2 implies the indication of axillary lymph node micrometastasis. Breast cancer patients with HER-2 positive expression in axillary lymph node have poor prognosis. Trastuzumab can improve the prognosis of patients with micrometastasis of axillary lymph nodes.

Key words： Breast Neoplasms Receptor, ErbB-2 Polymerase Chain Reaction Lymph Nodes

Received: 01 September 2021

PACS:

R737.9

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	FAN Zhou
	FAN Pei-zhi

Cite this article:

FAN Zhou,FAN Pei-zhi. Clinical Significance of HER-2 Expression Detection by PCR in Axillary Lymph Nodes of StageⅠBreast Cancer with HER-2-postive[J]. JOURNAL OF CLINICAL RESEARCH, 2022, 39(1): 44-47.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.01.012 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I1/44

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