KL-6、SP-A 及SP-D对儿童间质性肺疾病早期诊断及预后的评估价值

doi:10.3969/j.issn.1671-7171.2022.01.002

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Abstract 【Objective】To analysis the value of Krebs von den Lungen-6 (KL-6), lung Surfactant Protein A (SP-A) and lung Surfactant Protein D (SP-D) for the early diagnosis and prognosis assessment of interstitial lung disease (ILD)in children. 【Methods】A total of 35 children with interstitial lung disease (ILD) hospitalized in Department of Respiratory Medicine of Hunan Children's Hospital from March 2016 to July 2020 were selected as the ILD group, while 40 children hospitalized with infectious pneumonia during the same period were selected as the pneumonia group and 40 healthy children volunteers were selected as the control group. Clinical data of children in the three groups were collected to detect pulmonary function indicators of children in the three groups. Kl-6 was detected by chemiluminescent enzyme immunoassay, and SP-A and SP-D were detected by enzyme-linked immunoassay. The value of all three factors in early diagnosis and prognosis evaluation of interstitial pulmonary disease was analyzed. 【Results】The levels of KL-6, SP-A and SP-D in ILD group were higher than those in pneumonia group and control group (P<0.01). The level of serum KL-6 was positively correlated with maximum vital capacity (VC max) and one second rate (FEV₁/FVC) (r_s=0.339, P<0.05), while the level of SP-A was negatively correlated with 25% maximum expiratory flow (MEF25) (r_s=-0.252, P<0.05) and the level of SP-D was negatively correlated with VC max (r_s=-0.214, P<0.05). Pulmonary interstitial lesion score was positively correlated with KL-6, SP-A and SP-D (r_s=0.542、0.618、0.515,P<0.01). The AUC,sensitivity, specificity and Youden index of KL-6, SP-A and SP-D combined detection were 0.89, 83.6%, 97.2% and 0.81, respectively, indicating that the combined detection of three parameteers was better than the single detection in the diagnosis of ILD. KL-6, SP-A and SP-D were the influencing factors for the prognosis of ILD children(P<0.05). 【Conclusion】KL-6, SP-A and SP-D can be used as indicators of early diagnosis, disease severity and prognosis of interstitial lung disease in children, and their combined detection application can improve the diagnostic accuracy.

Key words： Lung Diseases, Interstitial Pulmonary Surfactant-Associated Protein A/BL Pulmonary Surfactant-Associated Protein D/BL Diagnosis Prognosis Child

Received: 01 September 2021

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R725.63

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2022.01.002 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2022/V39/I1/5

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