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| Efficacy and Safety of Different Combinations of Mifepristone in the Induced Labor of the Second Trimester of Scarred Uterus |
| WU Qun-ying, WANG Xiao-yu |
| Department of Obstetrics and Gynecology, Weinan Central Hospital, Weinan Shaanxi 714000 |
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Abstract 【Objective】To compare the efficacy and safety of different combinations of mifepristone in the induction of labor in the second trimester of scarred uterus. 【Methods】A retrospective analysis of 90 cases of women in second trimester of scarred uterus who received labor induction in Weinan Central Hospital from December 2015 to December 2019 was conducted. Patients were divided into the mifepristone + double balloon group (28 cases, group A) ,mifepristone + carprost methyl ester group(32 cases, group B) and mifepristone + esacridine lactate group (30 cases, group C) according to the method of labor induction. The cervical Bishop score, labor induction effect, labor induction bleeding and complications of the three groups were compared. 【Results】After induction of labor, the cervical Bishop score of the mifepristone + double balloon group was > the mifepristone + carprost methyl group>the mifepristone + esacridine lactate group; the difference was statistically significant (P<0.05). The effective rate of the mifepristone + esacridine lactate group was lower than that of the mifepristone + double balloon group and the mifepristone + carboprost methylester group, while the efficiency rate of the mifepristone + esacridine lactate group was higher than that of the mifepristone + double balloon group and the mifepristone + carprost methyl ester group. The differences were statistically significant (P<0.05). However, there was no statistically significant difference in the effective rate and successful induction rate among the three groups (P> 0.05). The time from the beginning of the birth process to the delivery of the fetus plus the total induction time in mifepristone + esacridine lactate group was longer than those in the mifepristone + double balloon group and the mifepristone + carboprost methylester group (P<0.05). There were no statistically significant differences in the bleeding volume, the time from inducing labor to effective contractions, the incidence of complications and the incidence of adverse reactions in the three groups (P> 0.05). 【Conclusion】The combination of mifepristone with balloon, carprost methyl ester and ethacridine lactate is feasible in the induction of labor in the second trimester of scar uterus, however, the combination of mifepristone with double balloon has higher cervical maturity and shorter induction time.
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Received: 08 March 2021
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2021, Vol. 38 
