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| Diagnostic Value of IgG, IgE and CA19-9 in Autoimmune Pancreatitis |
| ZHU Feng-bo, YANG Ying, LI Qiu-xia |
| The Fifth People's Hospital of Jinan,Jinan 250022 |
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Abstract 【Objective】 To detect the levels of IgG, IgE and CA19-9 in patients with AIP, and to evaluate the diagnostic value of single and combined detection for AIP. 【Methods】 From January 2016 to June 2020, 112 patients with pancreatitis in our hospital were selected, including 54 patients with acute pancreatitis (AP group), 23 patients with chronic pancreatitis (CP Group), 35 patients with type 1 AIP (AIP group), and 30 healthy volunteers (control group) in our hospital during the same period, The sensitivity and specificity of IgG4, IgE and CA19-9 in the diagnosis of AIP were detected by drawing the receiver operating curve.【Results】 There was no significant difference in serum IgG1, IgG2 and IgG3 levels among the four groups (P>0.05); The serum IgG4 levels of the four groups were significantly higher than those of the control group (P<0.05). There were significant differences in serum IgG, CA19-9 and IgE levels among the four groups (P<0.05). The serum IgG levels in the AP group, the CP Group and the AIP group were higher than those in the control group, and the Serum CA19-9 and IgE levels in the AIP group were higher than those in the AP group, the CP Group and the control group. ROC curve was drawn. The results showed that the sensitivity and specificity of combined detection of IgG4, IgE and CA19-9 were 87.3% and 94.1% respectively, which were higher than those of single detection of each index.【Conclusion】 The levels of IgG4, IgE and CA19-9 in AIP patients were higher than those in AP and CP patients. The combined detection of the three can improve the sensitivity and specificity in the diagnosis of AIP.
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Received: 24 November 2020
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[1] 吴朝锐,刘立国,赵东兵.1型自身免疫性胰腺炎与胰腺癌的鉴别诊断进展[J].中华普通外科杂志,2018,33(9):800-805.
[2] 李家速,刘枫,李兆申.自身免疫性胰腺炎临床特征的研究新进展[J].中华胰腺病杂志,2018,18(4):286-288.
[3] MIYAMOTO Y, KAMISAWA T, TABATA T,et al. Short and long-term outcomes of diabetes mellitus in patients with autoimmune pancreatitis after steroid therapy[J].Gut Liver,2012 ,6(4):501-504.
[4] HIRANO K, TADA M, ISAYAMA H, et al. Clinical analysis of high serum IgE in autoimmune pancreatitis[J].World J Gastroenterol,2010,16(41):5241-5246.
[5] YAN T, KE Y, CHEN Y,et al. Serological characteristics of autoimmune pancreatitis and its differential diagnosis from pancreatic cancer by using a combination of carbohydrate antigen 19-9, globulin, eosinophils and hemoglobin[J].PLoS One,2017,12(4):e0174735.
[6] 中华医学会消化病学分会胰腺疾病学组,中华胰腺病杂志编辑委员会,中华消化杂志编辑委员会.中国急性胰腺炎诊治指南(2013年,上海)[J].中华消化杂志,2013,33(4):217-222.
[7] 中国医师协会胰腺病专业委员会慢性胰腺炎专委会.慢性胰腺炎诊治指南(2018,广州)[J].临床肝胆病杂志,2019,35(1):45-51.
[8] 《中华胰腺病杂志》编委会.我国自身免疫性胰腺炎诊治指南(草案 2012,上海)[J].中华胰腺病杂志,2013,13(1):43-45.
[9] 夏长胜,樊春红,王辉.血清IgG4和IgG4/IgG比值诊断Ⅰ型自身免疫性胰腺炎的最佳临界值及性能评价[J].检验医学,2019,34(4):322-326.
[10] TERUMI K,KAZUICHI O,SHIGEYUKI K.Diagnostic criteria for autoimmune pancreatitis in Japan[J].World J Gastroenterol,2008,14(32):4992-4994.
[11] CARRUTHERS M N, KHOSROSHAHI A, AUGUSTIN T, et al. The diagnostic utility of serum IgG4 concentrations in IgG4-related disease[J].Ann Rheum Dis,2015, 74(1):14-18.
[12] LIAN M J, LIU S, WU G Y, et al. Serum IgG4 and IgG for the diagnosis of autoimmune pancreatitis: A systematic review with meta-analysis[J].Clin Res Hepatol Gastroenterol,2016 ,40(1):99-109.
[13] 华勇.生长抑素辅以肠内营养支持治疗急性胰腺炎的效果及对免疫状态和炎性因子的影响[J].医学临床研究,2018,35(12):2369-2371.
[14] 范明鑫,刘霞.25(OH)D3、IgE和FeNO在哮喘患者血清中的表达及其临床意义[J].医学临床研究,2019,36(5):988-989.
[15] 王艾丽, 严孝岭,刘国瑞,等.南京地区变应性鼻炎患者吸入性变应原特异性IgE 和总IgE 的检测分析[J].现代检验医学杂志,2012,27(3):101-103.
[16] KUSUDA T, UCHIDA K, SATOI S,et al. Idiopathic duct-centric pancreatitis (IDCP) with immunological studies[J].Intern Med,2010,49(23):2569-2575. |
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2021, Vol. 38 
