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| Study on Effects of Sevoflurane in Radical Resection of Lung Cancer and Its Influence on Vascular Endothelial Growth Factor, COX-2, MMP-2 and MMP-9 |
| BAI Wei-jie |
| Zhengzhou Orthopaedic Hospital,Zhengzhou Henan 450052 |
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Abstract 【Objective】 To investigate the effect of sevoflurane in radical resection of lung cancer and its influence on the levels of vascular endothelial growth factor, COX-2, MMP-2 and MMP-9 in patients with lung cancer. 【Methods】 A total of 80 patients undergoing radical resection of lung cancer in our hospital were divided into the control group and the observation group. The control group was given isoflurane inhalation anesthesia, while the observation group was given sevoflurane inhalation anesthesia. The anesthesia effect of the two groups was observed, and the differences of blood levels of vascular endothelial growth factor, COX-2, MMP-2 and MMP-9 between the two groups during perioperative period were compared. 【Results】 There was no difference in preoperative immune function between the two groups. Two hours after operation, the levels of CD3+ and CD4+ in the observation group were lower than those in the control group, while the level of CD8+ was higher than that in the control group (P<0.05). The levels of vascular endothelial growth factor, COX-2, MMP-2 and MMP-9 in the observation group at 2 hours after operation were lower than those in the control group. The VAS scores of patients in the observation group at 4 hours and 12 hours after operation were 1.48±0.35) and 1.34±0.27), respectively, which were lower than those in the control group (2.11±0.42 and 2.15±0.55,respectively) (P<0.05). There was no significant difference in Ramsay scores between the two groups (P>0.05). The satisfaction rate of patients in the observation group was 97.50%, which was significantly higher than that of patients in the control group (82.50%).The difference between the two groups was significant (P<0.05). 【Conclusion】 Sevoflurane is effective in radical resection of lung cancer, and has little effect on the levels of vascular endothelial growth factor, COX-2, MMP-2 and MMP-9. It has good clinical application.
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Received: 25 May 2020
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2021, Vol. 38 
