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| Expression and Clinical Significance of IL-6, sFlt-1 and VEGF in Serum of Pregnant Women with Gestational Hypertension |
| WANG He-ping, LIU Guang-lian |
| Department of Obstetrics and Gynecology, Maternal and Child Health Family Planning Service Center of Luochuan County, Luochuan 727400 |
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Abstract 【Objective】 To observe the levels of serum interleukin-6 (IL-6), soluble vascular endothelial growth factor receptor 1 (sFlt-1), vascular endothelial growth factor (VEGF) in patients with pregnancy-induced hypertension and the relationship between academic indicators. 【Methods】 A total of 80 cases of pregnant women with gestational hypertension in our hospital from January to December 2020 were selected as the observation group, and 80 cases of normal pregnant women in the same hospital during the same period were selected as the control group. The levels of serum IL-6, sFlt-1, VEGF and hemorheology were detected and compared between the two groups, and the correlation of each index and the influencing factors of gestational hypertension were analyzed. 【Results】 The levels of IL-6, sFlt-1, whole blood low shear reduced viscosity (LRV), plasma viscosity (PV) and fibrinogen (Fib) in the observation group were significantly higher than those in the control group, and the levels of VEGF in the observation group were significantly lower than those in the control group (all P<0.05); However, there was no significant difference in HRV and MRV between the two groups (P>0.05). IL-6 was positively correlated with LRV and PV (P<0.05), sFlt-1 was positively correlated with LRV, PV and Fib (P<0.05), VEGF was negatively correlated with LRV, PV and Fib (P<0.05). Logistic analysis showed that IL-6, sFlt-1, LRV, PV and VEGF were the risk factors of pregnancy induced hypertension (P<0.05). 【Conclusion】 The serum levels of IL-6 and sFlt-1 are increased, VEGF is decreased and hemorheological indexes are abnormal; There is correlation between IL-6, sFlt-1, VEGF and hemorheology indexes. Clinical intervention can be carried out according to the above indexes to ensure the safety of mother and infant.
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Received: 03 November 2020
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2021, Vol. 38 
