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| Significance of Complement-related Factors and Anticardiolipin Antibody Detection in Pregnant Women with Preeclampsia |
| ZHAO Min, HAN Xing |
| Department of Obstetrics and Gynecology, Hanzhong Central Hospital, Shaanxi Hanzhong 723000 |
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Abstract 【Objective】 To analyze the levels and significance of maternal complement-related factors and anti-cardiolipin antibodies in preeclampsia. 【Methods】 The clinical data of 66 patients with preeclampsia (preeclampsia group) and 54 patients with severe preeclampsia (severe preeclampsia group) who gave birth in our hospital from December 2016 to March 2018 were selected for retrospective analysis. Thirty-six normal women at the same time were selected as the control group. Placental tissue, serum complement factor D (CFD), adiponectin (ADPN) levels, and serum anticardiolipin antibody (ACA) levels were measured in all maternal women. The expression levels of each factor in the two groups were compared. 【Results】 The levels of CFD in severe preeclampsia were significantly higher than those in the control group and preeclampsia. The ADPN level was significantly lower than the other two groups (P<0.05). The levels of ACA-IgA, ACA-IgG and ACA-IgM in severe preeclampsia were significantly higher than those in the control group. The levels of ACA-IgA and ACA-IgG in severe preeclampsia were significantly higher than those in preeclampsia (P<0.05). 【Conclusion】 Compared with normal pregnant women, the pre-eclampsia maternal body CFD is at a high level, serum ACA-IgA, ACA-IgG and ACA-IgM expression are significantly higher than normal, and is proportional to the severity of the disease, while ADPN is at Low level state, and inversely proportional to the severity of the disease.
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Received: 14 October 2020
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(6): 954-956. |
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2021, Vol. 38 
