Perioperative Dynamics of cFN, Alb/HbA1c and IFN-γ in Patients with Traumatic Cerebral Hemorrhage undergoing Standard Large Trauma Craniotomy and Relationship with Neurological Function
WANG Xiao-li, WANG Yan-yan, YU Yan-hong
Shandong Provincial Third Hospital, Jinan Shandong,250031,China
Abstract【Objective】 To investigate the perioperative dynamics of cellular fibronectin (cFN), albumin (Alb)/glycated hemoglobin (HbA1c) and interferon-γ (IFN-γ) in patients with traumatic cerebral hemorrhage during standard large trauma craniotomy (SLTC) and analyze its relationship with neurological function. 【Methods】 A total of 219 patients with traumatic intracerebral hemorrhage who were scheduled to undergo SLTC surgery between May 2017 and February 2020 in our hospital were selected. According to the prognosis 30 days after operation, they were divided into a good prognosis group (107 cases) and a poor prognosis group (112 cases). The cFN, Alb/HbA1c, IFN-γ, the National Institutes of Health Stroke Scale (NIHSS), and Glasgow Coma Scale (GCS) scores were compared between the two groups. Pearson was used to analyze the correlation of cFN, Alb/HbA1c and IFN-γ with GCS score and NIHSS score. Receiver operating characteristic curve (ROC) and area under ROC (AUC) were used to analyze the efficacy of cFN, Alb/HbA1c, and IFN-γ in predicting prognosis. 【Results】 Compared to those before operation, serum levels of cFN, Alb/HbA1c, IFN-γ, GCS score, and NIHSS score between the two groups of patients at different times were differences; and the differences were statistically significant (P<0.05). If serum levels of cFN, Alb/HbA1c and IFN-γ, GCS score and NIHSS score at 3 and 7 days after operation were compared, there were statistically significant differences between the two groups (P<0.05). The cFN, Alb/HbA1c and IFN-γ at 3 and 7 days after operation were significantly correlated with the GCS score and NIHSS score at 3 and 7 days after operation (P<0.05). The serum cFN, Alb/HbA1c, and IFN-γ levels at 7 d after surgery were more effective in predicting prognosis than at 3 d after surgery. Among them, cFN had the largest AUC for predicting prognosis, which is 0.857.【Conclusion】 In SLTC patients with traumatic cerebral hemorrhage, cFN and IFN-γ tend to increase in the early postoperative period, while Alb/HbA1c tends to decrease. Detecting the level of each index on 7 days after operation can provide important reference information for clinical prediction of prognosis.
WANG Xiao-li,WANG Yan-yan,YU Yan-hong. Perioperative Dynamics of cFN, Alb/HbA1c and IFN-γ in Patients with Traumatic Cerebral Hemorrhage undergoing Standard Large Trauma Craniotomy and Relationship with Neurological Function[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(4): 522-525.
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2021, Vol. 38 
