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| Study on the Correlation of Serum Endogenous Growth Hormone Releasing Peptide and Oxidative Stress Media in Patients with Acute Pancreatitis |
| PAN Rong, DOU Zhen-feng |
| Department of Emergency,Jiading Central Hospital Shanghai University of Medicine & Health Sciences,ShangHai,201800,China |
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Abstract 【Objective】To detect the changes of serum endogenous growth hormone releasing peptide (Ghrelin), paraoxonase-1 (PON-1), superoxide dismutase (SOD) and malondialdehyde (MDA) in patients with acute pancreatitis (AP). 【Methods】A total of 195 patients with AP were selected as the research object (observation group), including 106 mild cases (mild group), 59 moderate cases (moderate group) and 30 severe cases (severe group). Another 45 healthy people were selected as control group. On the day of physical examination, venous blood samples were collected from patients with AP on D1, D3 and D7 for detection of endogenous Ghrelin, PON-1, SOD and MDA. The changes of the above indexes and the correlation between endogenous Ghrelin and PON-1, SOD and MDA were analyzed. 【Results】 The levels of serum endogenous Ghrelin, PON-1 and SOD in AP patients gradually decreased with the remission of the disease, and were lower than those in the control group, while the level of serum MDA was just the opposite, and the comparison among the groups was statistically significant (P<0.05). With the extension of admission time, the serum endogenous Ghrelin, PON-1 and SOD levels of AP patients gradually increased with the improvement of the disease, while the serum MDA level gradually decreased, with statistical significance at different time points in the same group (P<0.05). Spearman correlation showed that serum endogenous Ghrelin was positively correlated with PON-1 and SOD (r=0.335 and 0.414, P<0.001), and negatively correlated with MDA (r=-0.393, P<0.001). 【Conclusion】The level of serum endogenous Ghrelin decreases with the aggravation of AP, and is related to the oxidative stress mediators such as PON-1, SOD and MDA, which provides a basis for the early diagnosis of AP, the judgment of disease severity and the search for new therapeutic targets.
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Received: 06 November 2019
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2021, Vol. 38 
