慢性胃炎患者唾液Hp抗体IgG和粪便Hp抗原检测结果的临床意义

doi:10.3969/j.issn.1671-7171.2021.06.008

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Abstract 【Objective】To reveal the clinical significance of helicobacter pylori (Hp) antibody IgG (HpIgG) detection in saliva and Hp antigen in feces of patients with chronic gastritis. 【Methods】The patients with chronic gastritis who were treated in our hospital were selected as the observation group and healthy adults who had physical examination in our hospital during the same period were selected as the control group. The results of HpIgG in saliva and Hp antigen in feces of the two groups were observed. The differences of pepsinogen (PGⅠ and PGⅡ), G-17 (gastrin 17), cytokine hypersensitive C-reaction protein(hs-CRP) and cytokines (IL-18 and IL-6) levels between the two groups were compared. The correlation between the results of HpIgG in saliva and Hp antigen in feces of patients with chronic gastritis and the levels of PGⅠ, PGⅡ, G-17 and cytokines was analyzed. 【Results】In the observation group, the positive rates of HpIgG in saliva and Hp antigen in feces were 72.00% and 45.00%, respectively, which were higher than those in the control group (P<0.01). The levels of PGⅠ and PGⅡ in the observation group were lower than those in the control group, while the level of G-17 in the observation group was higher than that in the control group (P<0.01). The levels of IL-18, IL-6 and hs-CRP in the observation group were higher than those in the control group (P<0.01). The positive rates of HpIgG in saliva and Hp antigen in feces of patients in the observation group were negatively correlated with the levels of PGⅠ and PGⅡ, and positively correlated with the levels of G-17, IL-18, IL-6 and hs-CRP (P<0.05). 【Conclusion】The positive rate of HpIgG in saliva and Hp antigen in feces is higher in patients with chronic gastritis, and it is related to pepsin and cytokine levels.

Key words： Gastritis Helicobacter Infections/CO Helicobacter pylori Saliva Feces

Received: 06 February 2020

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R573.3

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	ZHANG Xue-yan
	FAN Jie

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ZHANG Xue-yan,FAN Jie. Clinical Significance of Salivary Helicobacter Pylori (Hp) Antibody IgG and Fecal Hp Antigen Detection in Patients with Chronic Gastritis[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(6): 831-833.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.06.008 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I6/831

[1] 喻德林, 胡希亚.幽门螺杆菌根除性治疗对慢性胃炎患者胃泌素及细胞因子的影响[J].现代消化及介入诊疗, 2016, 21(4):619-622.
[2] JANKOWSKI M.Detection of gastric Helicobacter spp.in stool samples of dogs with gastritis.[J].Pol J Vet Sci,2016, 19(2):237-243.
[3] 段云燕, 成映霞, 王强,等.香砂六君子汤对脾胃虚弱型萎缩性胃炎大鼠胃排空功能及胃蛋白酶活性和缺氧诱导因子-1α表达的影响[J].中国中医药信息杂志, 2016, 23(1):47-51.
[4] IENI A, BARRESI V, RIGOLI L, et al.Morphological and cellular features of innate immune reaction in Helicobacter pylori gastritis:a brief review[J].IJMS,2016, 17(1):109.
[5] 袁瑜, 梁芬芬, 钟豪杰.外周血胃蛋白酶原在萎缩性胃炎与浅表性胃炎鉴别诊断中的临床价值[J].中国实验诊断学, 2016, 20(11):1884-1886.
[6] Ribaldone D G, Simondi D, Astegiano M, et al.On inverse association between Helicobacter pylori gastritis and microscopic colitis:the european data[J].Inflamm Bowel Dis,2016, 22(1):182-186.
[7] 何坚, 石兴珍.血清胃蛋白酶原Ⅰ、Ⅱ和促胃液素-17在萎缩性胃窦炎诊断中的意义[J].宁夏医科大学学报, 2016, 38(4):453-456.
[8] 颜海帆,夏晨梅, 陈玲玲,等.血清胃蛋白酶原、幽门螺杆菌抗体联合检测对胃癌及癌前病变的早期预测价值[J].中国医师杂志, 2017, 19(5):767-769.
[9] LIU J, SUN L, QIAN X, et al.Association of nucleotide excision repair pathway gene polymorphisms with gastric cancer and atrophic gastritis risks:[J].Oncotarget,2016, 7(6):6972-6983.
[10] 魏华, 张蕾蕾, 李艳,等.PGⅠ、PGⅡ、G-17和Hp IgG抗体筛查慢性萎缩性胃炎和胃癌的价值[J].中国免疫学杂志, 2016, 32(9):1360-1363.
[11] 王炳予, 袁星星, 杨磊,等.丹芪祛瘀止痛颗粒治疗气虚血瘀型慢性萎缩性胃炎疗效及对炎性因子和细胞因子的影响[J].现代中西医结合杂志, 2017, 26(30):3314-3317.

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2020, 37(8): 1121-1123.