Abstract 【Objective】To investigate the effect of lactitol powder combined with Xuebijing injection in the treatment of bacterial peritonitis and its influence on inflammatory mediators, total bilirubin (TBIL) and prostaglandin E2 (PGE2). 【Methods】A total of 88 patients with bacterial peritonitis admitted to our hospital from March 2018 to April 2020 were selected and divided into two groups by random number table, with 44 cases in each group. On the basis of conventional treatment, the control group was given lactitol powder, and the observation group was given lactitol powder combined with Xuebijing injection. The efficacy and the recovery time of clinical symptoms and signs after 2 courses of treatment, liver function indexes [serum alanine aminotransferase (ALT), total bilirubin (TBIL), albumin (Alb), aspartate aminotransferase (AST)], serum PGE2, pre-granulin (PGRN) before treatment, after treatment and adverse reactions were compared between the two groups. 【Results】The total effective rate (88.64%) of the observation group after 2 courses of treatment was higher than that of the control group (70.45%) (P<0.05). The time of body temperature returning to normal, the time of abdominal pain disappearing, the time of stopping diarrhea, the time of abdominal tenderness disappearing, and the negative time of ascites culture in the observation group were shorter than those in the control group (P<0.05). After 1 and 2 courses of treatment in the observation group, ALT, TBIL and AST were lower than the control group, and Alb was higher than the control group (P<0.05). After 2 courses of treatment in the observation group, PGE2 was higher than the control group, and PGRN was lower than the control group (P<0.05). The incidence of adverse reactions in the observation group was 2.27% (1/44), compared with 6.82% (3/44) in the control group, there was no statistically significant difference (P>0.05). 【Conclusion】Lactitol powder combined with Xuebijing injection in the treatment of bacterial peritonitis can speed up the recovery of clinical symptoms and signs, improve liver function. It has a significant effect and high safety.
GUAN Min,WANG Yong,LI Ru-dong. Effect of Lactitol Powder and Xuebijing Injection on Bacterial Peritonitis and Its Influence on PGRN and PGE2[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(1): 110-113.
[1] Elfessi Z,Liu E,Dukarevich Y,,et al.Sepsis induced bacterial peritonitis caused by Granulicatella adiacens[J].Am J Emerg Med.Sepsis induced bacterial peritonitis caused by Granulicatella adiacens[J].Am J Emerg Med,2019,37(12):2263.e1-2263.e3. [2] Elloumi H,Sabbah M,Bibani N,et al.Effect of low dose albumin administration in spontaneous bacterial peritonitis on renal function and survival[J].Arab J Gastroenterol,2019,20(4):205-208. [3] 单红艳,殷景远,夏奇彩.拉克替醇散防治产后便秘的疗效及安全性临床观察[J].中南药学, 2018,16(2):120-122. [4] 房新辉,李健.血必净注射液对慢加急性肝衰竭合并自发性腹膜炎患者凝血功能和肝功能及炎性因子水平的影响[J].新乡医学院学报,2018,35(11):997-1000. [5] 中华医学会肝病学分会.肝硬化腹水及相关并发症的诊疗指南[J].中华肝脏病杂志,2017,25(9):664-677. [6] Ferrarese A,Pellone M,Cattelan AM,et al.Antibiotic therapy for spontaneous bacterial peritonitis in acute-on-chronic liver failure: Handle with care[J].Dig Liver Dis,2020,52(1):116-117. [7] 魏媛媛,胡立芬,李家斌.自发性腹膜炎肠道菌群的变化研究[J].中华疾病控制杂志,2018,22(5):105-107. [8] Li XQ,Zhang XM,Wu X,et al.Beneficial effects of lactitol on the composition of gut microbiota in constipated patients[J].J Dig Dis,2020,21(8):445-453. [9] Sun R,Liang M,Yang H,et al.Effect of Xuebijing on inflammatory response and prognosis in patients with septic shock[J].Chin Crit Care Med,2020,32(4):458-462. [10] 罗俊力. 腹水前列腺素E2在诊断自发性腹膜炎和预测住院死亡率中的价值研究[D].重庆医科大学,2019:6-18. [11] 彭官清,凌乔,潘沛沛,等.肝硬化并发自发性细菌性腹膜炎患者血清中颗粒蛋白前体水平及临床意义[J].中华医院感染学杂志,2019,29(23):3558-3562.
2021, Vol. 38 
