非人类免疫缺陷病毒感染的肺孢子菌肺炎患者的临床特征

doi:10.3969/j.issn.1671-7171.2021.03.016

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Abstract 【Objective】To investigate clinical characteristics of pneumocystis pneumonia(PCP) in non-HIV-infected patients. 【Methods】 The clinical data of non HIV infected PCP patients diagnosed and treated in respiratory and critical care medicine department of our hospital from October 2018 to September 2019 were collected, and their clinical characteristics were analyzed.【Results】 Forty five patients were included in the study, and 19 (42.2%) died. The most common underlying diseases are autoimmune diseases, followed by malignant tumors, solid organ transplantation and kidney diseases; the main manifestations of PCP patients are nonspecific fever, cough and dyspnea, and the typical chest CT images are multiple or scattered ground glass shadows in both lungs. Compared with the patients who survived in hospital, the dead patients had lower albumin (33.9 ± 5.0 vs 27.7 ± 4.3), higher lactate dehydrogenase (390.7 ± 189.1 vs 524.1 ± 246.9), higher plasma urea nitrogen level [6.1 (5.2-8.0) vs 9.4 (5.0-15.5)] and worse oxygenation index [371.4 (316.2-423.8) vs 300.0 (257.1-354.8)], the differences were statistically significant (all P <0.05). After admission, 44 cases were treated with compound sulfamethoxazole anti PCP, 31 cases were treated with caspofungin; 41 cases (91.1%) were treated with glucocorticoid on the basis of anti infection.【Conclusion】The mortality of PCP patients without HIV infection is higher, and the prognosis of patients with low albumin, increased plasma lactate dehydrogenase and urea nitrogen and poor oxygenation index on admission is poor.

Key words： Pneumonia Bacterial Prognosis Survival Rate

Received: 25 November 2019

PACS:

R563.1

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	CHEN Xue-ying
	WANG Qi
	XU Yong-jian
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Cite this article:

CHEN Xue-ying,WANG Qi,XU Yong-jian, et al. Clinical Characteristics of Pneumocystis Pneumonia Patients with Non-human Immunodeficiency Virus Infection[J]. JOURNAL OF CLINICAL RESEARCH, 2021, 38(3): 375-378.

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http://journal07.magtech.org.cn/yxlcyj/EN/10.3969/j.issn.1671-7171.2021.03.016 OR http://journal07.magtech.org.cn/yxlcyj/EN/Y2021/V38/I3/375

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