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| Effects of Lp-PLA2, hs-CRP and D-dimer on the Occurrence and Development of Coronary Heart Disease |
| YU Mao-wen |
| West China Hospital Sichuan University Jintang Hospital,chengdu 610400, Sichuan |
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Abstract 【Objective】To investigate the correlation of serum lipoprotein associated phospholipase A2 (Lp-PLA2), high sensitivity C-reactive protein (hs CRP) and D-dimer levels with coronary heart disease.【Methods】A total of 100 patients with coronary heart disease admitted to our hospital from October 2018 to may 2019 were selected as the research objects, and they were divided into acute myocardial infarction group, stable angina pectoris group and unstable angina pectoris group according to the severity of the patient's condition. Meanwhile, healthy volunteers who had physical examination in our hospital during the same period were selected as the control group. The levels of serum Lp-PLA2, hs CRP, D-dimer, blood lipids and cardiac function indexes were compared between patients with coronary heart disease and control group, as well as patients with different severity of coronary heart disease. The correlation between the levels of Lp-PLA2, hs-CRP, D-dimer and blood lipids and cardiac function indexes in patients with coronary heart disease was analyzed.【Results】 The levels of serum Lp-PLA2, hs CRP, D-dimer, NT-proBNP, CTnI, TC, TG and LDL-C in myocardial infarction group, unstable myocardial infarction group and stable myocardial infarction group were significantly higher than those in the control group, while the levels of LVEF and HDL-C were lower than those in the control group, and the differences between coronary heart disease groups were statistically significant (all P <0.05). Serum Lp-PLA2, hs-CRP and D-dimer levels were positively correlated with NT-proBNP, CTnI, TC, TG and LDL-C levels ( P <0.05), and negatively correlated with LVEF and HDL-C levels ( P <0.05). 【Conclusion】The serum levels of Lp-PLA2, hs-CRP and D-dimer in patients with coronary heart disease are higher, which are closely related to the indexes of heart function and blood lipid level, and can reflect the condition of patients to a certain extent.
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Received: 26 June 2019
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2021, Vol. 38 
