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| Effect of Continuous Blood Purification Combined with Plasma Exchange on Patients with Non Biliary Severe Acute Pancreatitis |
| FU Xin-ping, ZHAO Ying, SHANG Yan-ru |
| Shandong Provincial Third Hospital, hemodialysis room 250031 |
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Abstract 【Objective】 To observe the effects of daytime continuous blood purification combined with plasma exchange on inflammatory factors and intestinal mucosal barrier dysfunction in patients with non-biliary severe acute pancreatitis(SAP). 【Methods】 A total of 80 patients with non-biliary SAP treated in our hospital were random divided into two group. The blood purification group (groupA) received continuous daytime blood purification treatment, and the combination group( groupB) received at least one plasma exchange treatment based on the blood purification group. The therapeutic effects, inflammation indicators, intestinal mucosal barrier function, complications and death were compared between the two groups. 【Results】 The total effective rate of combination group (87.5%) was higher than that of blood purification group (65.0%) (P<0.05). After treatment, the levels of serum amylase and lipase in the two groups were lower than those before treatment (all P<0.05), and those in the combined group were lower than those in the blood purification group (mean P<0.05). After treatment, CRP, TNF-αand procalcitonin in the two groups were lower than before treatment (all P<0.05), and the combined group was lower than the blood purification group (mean P<0.05). After treatment, endotoxin, diamine oxidase and D-lactate in the two groups were lower than before treatment (all P<0.05), and the combined group was lower than the blood purification group (mean P<0.05). The incidence of new complications in the combined group was lower than that in the blood purification group (20.0% vs 35.0%), but the difference was not significant (P>0.05), and the mortality of the two groups (5.0% vs 7.5%) was not significant (P>0.05). 【Conclusion】 Compared with daytime continuous blood purification alone, combined with plasma exchange can improve the curative effect of non biliary sap, improve gastrointestinal function and inflammatory level, and has high safety.
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Received: 30 October 2020
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2021, Vol. 38 
