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| Correlation between Serum Prealbumin with Activity and Early Renal Injury in Patients with Systemic Lupus Erythematosus |
| WANG Li-na, HUA Sha, LI Xiao-ming |
| Department of Rheumatology and Immunology, Xi'an Fifth Hospital, Xi'an, Shaanxi 710000 |
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Abstract 【Objective】 To investigate the correlation between serum prealbumin(PA) and systemic lupus erythematosus(SLE) activity and early renal injury. 【Methods】 According to SLEDAI score, 103 SLE patients were divided into mild activity group (42 cases), moderate activity group (25 cases) and severe activity group (36 cases); meanwhile, according to glomerular filtration rate (EGFR), the patients were divided into normal renal function group (49 cases) and abnormal renal function group (54 cases). Age, height, body mass, systolic blood pressure (SBP), diastolic blood pressure (DBP), platelet (PLT), hemoglobin (Hb), serum albumin (ALB), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), high sensitivity C-reactive protein (hs-CRP), serum creatinine (SCr), blood urea nitrogen (BUN), serum uric acid (UA), β2 microglobulin (β2MG),24 h urinary protein (UTP), erythrocyte sedimentation rate (ESR), complement C3 (C3), complement C4 (C4) and serum PA were collected .Binary logistic regression was used to analyze the risk factors of renal function injury, and the correlation between PA and the above risk factors was analyzed. ROC curve was used to evaluate the value of serum PA in predicting renal function injury.【Results】 (1) In different SLEDAI scores, PA level was the highest in mild activity group, followed by the moderate activity group, and the lowest in the severe activity group (P<0.05). (2) The level of PA in the normal renal function group was (212.34±60.92) mg/L, which was significantly higher than that in the abnormal renal function group (178.23±62.09) mg/L (P<0.05). (3) Age, UA and Hb were independent risk factors for renal dysfunction. Pearson correlation analysis showed that PA was positively correlated with age (P<0.05), and negatively correlated with UA and Hb (P<0.05). (4) The area under the curve (AUC) of ROC was 0.764, the sensitivity and specificity were 67.2% and 72.9% respectively.【Conclusion】 PA is correlated with SLE activity and renal injury, and can be used as one of the indexes to evaluate SLE activity and renal injury.
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Received: 07 November 2019
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2021, Vol. 38 
