Abstract【Objective】To investigate the prognosis of selective intrauterine growth restriction (sIUGR) in MCDA twin pregnancy. 【Methods】A total of 85 cases of MCDA pregnancy with sIUGR diagnosed and treated in our hospital from January 2018 to December 2019 were selected as the observation group, and 79 cases of normal pregnancy in the same period were selected as the control group. The prognosis of the normal group and the sIUGR group was compared. 【Results】The gestational weeks of delivery in the sIUGR group were earlier than those in the normal group, the difference in birth weight was greater than that in the normal group, and the incidence of intrauterine death (IUFD) was higher than that in the normal group (P<0.01); the gestational weeks of delivery in the type Ⅱ sIUGR group were earlier than those in type Ⅰ and type Ⅲ, the difference of birth weight was greater than that of type Ⅰ and type Ⅲ, and the incidence of IUFD was higher than that of type Ⅰ and Ⅲ (P<0.01).The incidence of abnormal umbilical cord in the sIUGR group was higher than that in the normal group. 【Conclusion】The prognosis of MCDA twins complicated with sIUGR is poor. The incidence of preterm birth, poor birth weight and intrauterine mortality rate of small fetus are higher in type Ⅱ sIUGR twins. Ultrasonography can accurately classify sIUGR and has important value for clinical prognosis evaluation.