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| Correlation between NT-proBNP Level and Cardiac Remodeling in Elderly Hypertensive Patients with Preserved Ejection Fraction |
| YAN Lin-zhen, DING Xiao-qing, YAN Fa-jia, et al |
| People's Hospital of Guangrao County, Dongying City,Shandong 257300 |
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Abstract 【Objective】 To investigate the correlation between N-terminal pro brain natriuretic peptide (NT-proBNP) and cardiac remodeling in elderly patients with hypertension and ejection fraction preserved heart failure (HFPEF).【Methods】 A total of 306 elderly patients with hypertension were selected as the research objects. The patients with HFpEF were included in the HFpEF group (n=96), the patients with heart failure HFrEF) with reduced ejection fraction (HFrEF) were included in the hfref group (n=52), the patients with heart failure with intermediate ejection fraction (HFmrEF) were included in the HFmrEF group (n=50), and the patients with simple hypertension were included in the control group (n=108). The general information, left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD) and maximum early diastolic velocity (E) of mitral valve orifice were compared among the four groups The ratio of peak to peak a (E/A), cardiac index (CI), left ventricular mass index (LVMI), NT-proBNP. Spearman rank correlation or Pearson correlation coefficient were used to analyze the correlation between cardiac function, NT-proBNP and cardiac remodeling.【Results】 There were significant differences in serum NT-proBNP level, E/A, LVMI, CI between the four groups (P<0.05); LVEF, LVEDD, E/A, LVMI among the HFpEF group, the HFmrEF group and then HFrEF group were statistically significant (P<0.05). Spearman correlation analysis showed that NT-proBNP was negatively correlated with LVEF and E/A (P<0.01); NT-proBNP was positively correlated with LVEDd and LVMI (P<0.01); cardiac function classification was positively correlated with LVMI, LVEDD, NT-proBNP (P<0.05), and cardiac function classification was negatively correlated with LVEF and E/A (P<0.05). Pearson correlation analysis showed that there was no significant correlation between NT-proBNP and LVEDD, E/A, LVMI in the HFmrEF group (all P>0.05), but only significant correlation with LVEF (r=0.315, P=0.026); there was no significant correlation between NT-proBNP and LVEF, LVEDD, E/A, LVMI in the HFrEF group (P>0.05).【Conclusion】 NT-proBNP is negatively correlated with E /A and LVEF in elderly patients with hypertension complicated with HFpEF; it is positively correlated with LVEDD and LVMI, which has higher screening value for HFpEF, but the application value of echocardiography in HFmrEF and HFrEF patients still needs further study.
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Received: 02 August 2019
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2020, Vol. 37 
